The effects of polymorphisms in the CX3CR1 gene on the development of canine hip dysplasia

Basit Öğe Kaydı
dc.authoridKÖK, SÜLEYMAN/0000-0002-9677-3571
dc.authorwosidKÖK, SÜLEYMAN/I-1376-2014
dc.contributor.authorAtalay, Sertac
dc.contributor.authorKok, Suleyman
dc.date.accessioned2024-06-12T10:59:01Z
dc.date.available2024-06-12T10:59:01Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractHip dysplasia, caused by both environmental and genetic components, is a common disorder characterized by hip instability in humans and dogs. Unfortunately, the genetic mechanisms that cause the disease in both have not been fully determined. The aim of this study was polymorphisms in the exon 2 and 3' UTR regions of the CX3CR1 gene were determined and their effects on the development of Canine Hip Dysplasia (CHD) in three dog breeds (German Shepherd, Belgian Malinois, Labrador Retriever). For this purpose, a case -control study was designed with 172 dogs in Dog Breeding and Training Center (DBTC) in Turkey. Each dog was evaluated according to the Norberg angle by the DBTC veterinarians. One hundred and seventeen dogs (32 German Shepherds, 49 Belgian Malinois, 36 Labrador Retrievers) classified as normal were included in the control group, and fifty - five dogs (24 German Shepherds, 14 Belgian Malinois, 17 Labrador Retrievers) diagnosed with CHD were included in the case group. Molecular genetic analyzes were performed with blood samples taken from each dog. Seven previously identified SNPs (g.8938599_8938600insCC, g.8937121G>A, g.8937137A>G, g.8937319T>G, g.8937441T>C, g.8937450A>G, g.8937590C>T) and a rare novel deletion (g. 8937205_ 8937206del) were identified in the 3' UTR regions of the CX3CR1 gene. The distribution of SNPs alleles in the case and control was compared by means of statistical analysis at allelic, genotypic, haplotypic, and SNP - SNP interaction levels. Single SNP analysis revealed that g.8937121G>A was significantly associated with susceptibility to CHD in Belgian Malinois (p = 0.00049) in the codominant model. Five SNP - SNP interactions were identified to be associated with CHD in Labrador Retrievers and the most suggestive of these was between g.8938599_8938600insCC and g.8937450A>G (p = 0.0004). We found that one haplotype block, consisting of two SNPs (g.8937137A>G and g.8937319T>G) was associated with susceptibility to CHD in Belgian Malinois (p = 0.022). None of the detected polymorphisms was statistically significantly associated with CHD in German Shepherds.en_US
dc.description.sponsorshipScientific Research Projects Commission of Trakya University [TUBAP-2018-139]en_US
dc.description.sponsorshipThe present study has been supported by the Scientific Research Projects Commission of Trakya University with the project number TUBAP-2018-139.en_US
dc.identifier.doi10.3906/vet-2105-69
dc.identifier.endpage87en_US
dc.identifier.issn1300-0128
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85125177322en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage74en_US
dc.identifier.trdizinid526913en_US
dc.identifier.urihttps://doi.org/10.3906/vet-2105-69
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/526913
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20287
dc.identifier.volume46en_US
dc.identifier.wosWOS:000752209200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Veterinary & Animal Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCX3CR1en_US
dc.subjectSNPen_US
dc.subjectHip Dysplasiaen_US
dc.subjectDog Breedsen_US
dc.subjectExome Sequencing Identifyen_US
dc.subjectChondrocyte Apoptosisen_US
dc.subjectShared Varianten_US
dc.subjectOsteoarthritisen_US
dc.subjectMicrornasen_US
dc.subjectPromotesen_US
dc.subjectLocien_US
dc.titleThe effects of polymorphisms in the CX3CR1 gene on the development of canine hip dysplasiaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu