Expression of ER stress markers (GRP78 and PERK) in experimental nephrotoxicity induced by cisplatin and gentamicin: roles of inflammatory response and oxidative stress

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dc.authoridYoldaş, Atilla/0000-0002-7807-0661
dc.authoridAltıntaş Aykan, Duygun/0000-0001-8224-4006
dc.authoridBayrak, Gülsen/0000-0002-1397-7203
dc.authoridOzcan Metin, Tuba/0000-0003-0624-026X
dc.authoridCoskun Yilmaz, Banu/0000-0002-7723-9146
dc.authoridSahin, Mehmet/0000-0001-8312-5156
dc.authorwosidYoldaş, Atilla/HKN-4466-2023
dc.authorwosidAyaz, Lokman/K-6716-2013
dc.authorwosidOzcan Metin, Tuba/HKF-6974-2023
dc.authorwosidMutlu, Gülşen/KCJ-8141-2024
dc.authorwosidAltıntaş Aykan, Duygun/JXL-7720-2024
dc.authorwosidBayrak, Gülsen/HJP-9011-2023
dc.authorwosidCoşkun Yılmaz, Banu/KAQ-6923-2024
dc.contributor.authorMetin, Tuba Ozcan
dc.contributor.authorBayrak, Gulsen
dc.contributor.authorYaman, Selma
dc.contributor.authorDoganer, Adem
dc.contributor.authorYoldas, Atila
dc.contributor.authorEser, Nadire
dc.contributor.authorAykan, Duygun Altintas
dc.date.accessioned2024-06-12T11:09:04Z
dc.date.available2024-06-12T11:09:04Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study aimed to establish the relationship between two endoplasmic reticulum (ER) stress proteins, glucose-regulated protein 78 (GRP78/BiP) and PKR-like endoplasmic reticulum kinase (PERK), and oxidative stress markers in cisplatin (CIS)-induced and gentamicin (GEN)-induced nephrotoxicity. The study consisted of five groups: control (saline solution only), CIS D2 (2.5 mg/kg for 2 days), CIS D7 (2.5 mg/kg for 7 days), GEN D2 (160 mg/kg for 2 days), and GEN D7 (160 mg/kg for 7 days). All rats were sacrificed 24 h after the last injection for standard clinical chemistry, and ultrastructural and histological evaluation of the kidney. CIS and GEN increased blood urea nitrogen (BUN) and serum creatinine (Cr) levels, as well as total oxidant status (TOS), while decreasing total antioxidant status (TAS) level in CIS D7 and GEN D7 groups. Histopathological and ultrastructural findings were also consistent with renal tubular damage. In addition, expression of markers of renal inflammation (tumor necrosis factor-alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta)) and ER stress markers (GRP78 and PERK) was significantly increased in the kidney tissue of rats treated with CIS and GEN for 7 days. These findings suggest that CIS and GEN administration for 7 days aggravates nephrotoxicity through the enhancement of oxidative stress, inflammation, and ER stress-related markers. As a result, the recommended course of action is to utilize CIS and GEN as an immediate but brief induction therapy, stopping after 3 days and switching to other drugs instead.en_US
dc.description.sponsorshipKahramanmaras Sutcu Imam University Department of Scientific Research Projects [2017/4-40 M]en_US
dc.description.sponsorshipThis work was supported by Kahramanmaras Sutcu Imam University Department of Scientific Research Projects (grant number: 2017/4-40 M).en_US
dc.identifier.doi10.1007/s00210-022-02358-5
dc.identifier.endpage801en_US
dc.identifier.issn0028-1298
dc.identifier.issn1432-1912
dc.identifier.issue4en_US
dc.identifier.pmid36482225en_US
dc.identifier.scopus2-s2.0-85143599308en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage789en_US
dc.identifier.urihttps://doi.org/10.1007/s00210-022-02358-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22678
dc.identifier.volume396en_US
dc.identifier.wosWOS:000895636900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNaunyn-Schmiedebergs Archives Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNephrotoxicityen_US
dc.subjectCisplatinen_US
dc.subjectGentamicinen_US
dc.subjectER Stressen_US
dc.subjectGRP78/BIPen_US
dc.subjectPERKen_US
dc.subjectEndoplasmic-Reticulum Stressen_US
dc.subjectPossible Mechanismen_US
dc.subjectApoptosisen_US
dc.subjectInhibitionen_US
dc.subjectKidneyen_US
dc.subjectAciden_US
dc.subjectRatsen_US
dc.subjectProtectsen_US
dc.subjectPathwayen_US
dc.subjectDamageen_US
dc.titleExpression of ER stress markers (GRP78 and PERK) in experimental nephrotoxicity induced by cisplatin and gentamicin: roles of inflammatory response and oxidative stressen_US
dc.typeArticleen_US

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