Kontrollü overyan hiperstimulasyon ile intrauterin inseminasyon sikluslarında hcg ile ovulasyon tetikleme gününde serum progesteron düzeylerinin gebelik oranları ile ilişkisi
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Çalışmamızda kontrollü overyan hiperstimülasyon ile İUİ planlanan hastalarda, kontrollü overyan hiperstimülasyon ile İUİ sikluslarında hCG ile ovulasyon tetikleme gününde serum progesteron düzeylerinin gebelik oranları ile ilişkisini araştırmayı amaçladık. Çalışmaya 25.03.2019 ile 1 Ocak 2020 tarihleri arasında Trakya Üniversitesi Sağlık Araştırma Ve Uygulama Merkezi Kadın Hastalıkları ve Doğum Anabilimdalı'na başvurup kontrollü overyan hiperstimülasyon ile İUİ planlanan 55 olgu dahil edildi. Olguların demografik özellikleri, obsetrik özgeçmişleri, menstrüel siklusun 2. günü bakılan FSH, LH, Estrodiol ve Progesteron düzeyleri, ovülasyon günü FSH, LH, Estrodiol ve Progesteron düzeyleri, spermatogram ve işlem sonrası gebelik durumları incelenerek elde edilen veriler kaydedildi. İstatistiksel analiz SPSS 20.0 paket programında hesaplandı. Sonuçlar karşılaştırılıp anlamlı fark olup olmamasına göre rapor edildi. Olguların yaşı ortalama 29,73 ± 4,54 yıl, infertilite süreleri ortalama 50,00 ± 34,40 ay olarak hesaplandı. Olguların hCG uygulama gününde ölçülen progesterone düzeyi 0,91 ± 1,11 ng/mL olarak hesaplandı. hCG uygulanan günde çapı 10 mm'nin üstünde folikül sayısı >3 olan olguların, folikül sayısı <3 olan olgulara göre gebelik görülme oranı istatistiksel olarak anlamlı fazla bulundu (p=0,012). Gebe olan ve olmayan olgularda yaş, infertilite süresi, menstrüel 2.günde ve hCG uygulama gününde ölçülen hormonal parametreler açısından hiçbir fark bulunmadı. Olguların gebelik durumları ile hCG yükleme gününde progesteron düzeyleri arasında istatistiksel ilişki görülmedi. Fakat gebeliği olan hastaların hepsinin progesteron değerinin <1.5 ng\ml altında olduğu görüldü. Primer infertiller ile sekonder infertiller arasında yapılan indüksiyon sonrası gebe kalma durumu konusunda istatistiksel olarak fark bulunmadı. İnfertilkite toplumun %10 ile 15'ini ilgilendirmekte olup çiftlerin tüm dünyada yaygın sorunu olarak bilinmektedir. Çalışmamızda infertile olgularda hCG yükleme gününde bakılan progesterone düzeyleri ile gebelik arasındaki ilişki bulunmadı. Fakat gebe olguların hepsinde progesteron düzeylerinin 1.5 ng/mL altında olduğu görüldü. Birçok çalışmada bu konuda farklı bir çok cut off değer bulunmuş olup; progesterone düzeyinin düşük olmasının gebelik için iyi olduğu ve literatürde birçok çalışmada hCG günü bakılan progesteronun gebelik üzerinde ters yönde etkisinin olduğu görülmüştür.
The Relationship Of Serum Progesterone Levels To The Pregnancy Ratios Of Ovulation Trigger Day On The Inspination Cycles Of Intrauter with Controlled Overyan Hyperstimulation. In our study, we aimed to investigate the relationship between serum progesterone levels and pregnancy rates on the day of ovulation triggering with hCG in IUI cycles with controlled ovarian hyperstimulation in patients scheduled for IUI with controlled ovarian hyperstimulation. The study included 55 patients who were admitted to the Department of Gynecology and Obstetrics of Trakya University Health Research and Application Center between 25.03.2019 and 1 January 2020, with controlled ovarian hyperstimulation. The data obtained by examining the demographic characteristics, obsetric CVs, FSH, LH, Estrodiol and Progesterone levels on the 2nd day of the menstrual cycle, FSH, LH, Estrodiol and Progesterone levels, spermatogram and post-operative pregnancy were recorded. Statistical analysis was calculated in SPSS 20.0 package program. The results were compared and reported according to whether there was a significant difference. The average age of the cases was calculated as 29.73 ± 4.54 years, and the duration of infertility was an average of 50.00 ± 34.40 months. Progesterone levels measured on the day of hCG application were calculated as 0.91 ± 1.11 ng / mL. The rate of gestation was found to be statistically significantly higher in cases with a follicle count> 3 over 10 mm in diameter per day with hCG compared to those with a follicle count <3 (p = 0.012). No difference was found in terms of age, infertility, menstrual 2nd day and hormonal parameters measured on hCG application day in pregnant and non-pregnant cases. There was no statistical relationship between pregnancy status of the patients and progesterone levels on the day of hCG loading. However, all patients with pregnancy were found to have a progesterone value below <1.5 ng \ ml. No statistically significant difference was found between primary infertiles and secondary infertiles after induction. Infertility concerns 10% to 15% of the society and is known as the common problem of couples worldwide. In our study, no relationship was found between the progesterone levels observed on the day of hCG loading and pregnancy in infertile cases. However, progesterone levels were found to be below 1.5 ng / mL in all pregnant cases. Many studies have found many different cut off values in this regard; Low progesterone level is good for pregnancy and it has been seen in many studies that progesterone on hCG day has adverse effects on pregnancy.
The Relationship Of Serum Progesterone Levels To The Pregnancy Ratios Of Ovulation Trigger Day On The Inspination Cycles Of Intrauter with Controlled Overyan Hyperstimulation. In our study, we aimed to investigate the relationship between serum progesterone levels and pregnancy rates on the day of ovulation triggering with hCG in IUI cycles with controlled ovarian hyperstimulation in patients scheduled for IUI with controlled ovarian hyperstimulation. The study included 55 patients who were admitted to the Department of Gynecology and Obstetrics of Trakya University Health Research and Application Center between 25.03.2019 and 1 January 2020, with controlled ovarian hyperstimulation. The data obtained by examining the demographic characteristics, obsetric CVs, FSH, LH, Estrodiol and Progesterone levels on the 2nd day of the menstrual cycle, FSH, LH, Estrodiol and Progesterone levels, spermatogram and post-operative pregnancy were recorded. Statistical analysis was calculated in SPSS 20.0 package program. The results were compared and reported according to whether there was a significant difference. The average age of the cases was calculated as 29.73 ± 4.54 years, and the duration of infertility was an average of 50.00 ± 34.40 months. Progesterone levels measured on the day of hCG application were calculated as 0.91 ± 1.11 ng / mL. The rate of gestation was found to be statistically significantly higher in cases with a follicle count> 3 over 10 mm in diameter per day with hCG compared to those with a follicle count <3 (p = 0.012). No difference was found in terms of age, infertility, menstrual 2nd day and hormonal parameters measured on hCG application day in pregnant and non-pregnant cases. There was no statistical relationship between pregnancy status of the patients and progesterone levels on the day of hCG loading. However, all patients with pregnancy were found to have a progesterone value below <1.5 ng \ ml. No statistically significant difference was found between primary infertiles and secondary infertiles after induction. Infertility concerns 10% to 15% of the society and is known as the common problem of couples worldwide. In our study, no relationship was found between the progesterone levels observed on the day of hCG loading and pregnancy in infertile cases. However, progesterone levels were found to be below 1.5 ng / mL in all pregnant cases. Many studies have found many different cut off values in this regard; Low progesterone level is good for pregnancy and it has been seen in many studies that progesterone on hCG day has adverse effects on pregnancy.
Açıklama
Tıpta Uzmanlık
Anahtar Kelimeler
Kadın Hastalıkları ve Doğum, Obstetrics and Gynecology
