Calprotectin can play an inflammatory role in acne vulgaris

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dc.authorwosidKorkmaz, Selma/W-4142-2017
dc.authorwosidKorkmaz, Selma/JRX-3713-2023
dc.contributor.authorKorkmaz, Selma
dc.contributor.authorFicicloglu, Sezin Kuru
dc.date.accessioned2024-06-12T10:50:28Z
dc.date.available2024-06-12T10:50:28Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: Acne vulgaris (AV) is a chronic inflammatory disorder of the pilosebaceous unit. Although various mechanisms have been indicated in the etiopathogenesis of acne vulgaris, the exact pathophysiology is still unknown. Aim: To investigate the level of calprotectin in acne vulgaris and its levels relationship with disease severity. Material and methods: A total of 66 AV patients, who were divided into 33 mild and 33 moderate-severe cases, and 30 healthy controls were enrolled in the study. Disease severity was assessed using the Global Acne Score. According to this scale, patients whose Global Acne Score was 1-18 had mild acne, those with a score of 19-30 had moderate acne, those with a score of 31-38 had severe acne, and those with a score greater than 39 had very severe acne. Serum calprotectin levels of all participants were measured by enzyme-linked immunosorbent assay method. Results: The serum calprotectin levels in the moderate-severe AV group were significantly higher than that of the mild AV group (p < 0.001). In addition, the scrum calprotectin level in the mild AV group was significantly higher than that of the healthy control group (p = 0.047). However, in the Spearman's correlation analysis, the scrum calprotectin level and GAS were not correlated in AV patients (p = 0.171, r = 0.179). Conclusions: Serum calprotectin levels are increased in mild and moderate AV patients.en_US
dc.identifier.doi10.5114/ada.2017.71286
dc.identifier.endpage399en_US
dc.identifier.issn1642-395X
dc.identifier.issue4en_US
dc.identifier.pmid30206454en_US
dc.identifier.scopus2-s2.0-85052111728en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage397en_US
dc.identifier.urihttps://doi.org/10.5114/ada.2017.71286
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17995
dc.identifier.volume35en_US
dc.identifier.wosWOS:000442539600012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofPostepy Dermatologii I Alergologiien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcne Vulgarisen_US
dc.subjectCalprotectinen_US
dc.subjectInflammationen_US
dc.subjectS100a9en_US
dc.titleCalprotectin can play an inflammatory role in acne vulgarisen_US
dc.typeArticleen_US

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