Sentinel lymph node mapping in patients with operable non-small cell lung cancer
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pioneer Bioscience Publ Co
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The aim of this study was to determine the accuracy and the role of the sentinel lymph node (SLN) in patients with non-small cell lung cancer. Material and method: This study was carried out on 25 consecutive patients [M/F=23:2, mean age 62.84 (47-81) years] with operable non-small cell lung cancer (NSCLC). At thoracotomy, 0.25 mCi of Technecium(99m) (99mTc) nanocolloid was injected into each quadrant of lung tissue surrounding the tumor. Before resection scintigraphic measurements of lymph nodes were obtained in vivo and ex vivo using a hand-held gamma probe counter and the findings were compared with histological examination. SLN was defined as the node with the highest count rate. Results: SLNs were identified in 23 of 25 patients (92%) with a total number of 52 SLNs. Seven of 52 (13%) of these SLNs were positive for metastatic involvement after histological and immunohistochemical examination. In two patients (8%), SLNs could not be found. The sensitivity and specificity were 55% and 86% respectively. Conclusions: This technic is a good method for identifying the first site of potential nodal metastases of NSCLC. These preliminary results demonstrate this procedure is feasible, but the detection rate has to be improved.
Açıklama
Anahtar Kelimeler
Non-Small-Cell Lung Carcinoma (NSCLC), Sentinel Lymph Node, 99mtc Nanocolloid, Lymph Node Intraoperative Detection, Nodal Dissection, Randomized-Trial, Dissection, Carcinoma, Prognosis, Survival, System
Kaynak
Journal Of Thoracic Disease
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
5
Sayı
3
