Association of MG53 with presence of type 2 diabetes mellitus, glycemic control, and diabetic complications

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dc.authoridyılmaz bülbül, buket/0000-0003-2651-0036
dc.authoridANDAC, BURAK/0000-0001-8680-0313
dc.authorwosidANDAÇ, BURAK/JEO-6641-2023
dc.authorwosidyılmaz bülbül, buket/JVZ-4676-2024
dc.contributor.authorAndac, Burak
dc.contributor.authorOzgun, Eray
dc.contributor.authorBulbul, Buket Yilmaz
dc.contributor.authorColak, Serpil Yanik
dc.contributor.authorOkur, Mine
dc.contributor.authorYekdes, Ali Cem
dc.contributor.authorOcal, Eftal
dc.date.accessioned2024-06-12T11:19:12Z
dc.date.available2024-06-12T11:19:12Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectivesMitsugumin 53 (MG53) is a myokine that acts as a membrane repair protein in tissues. Data on the effect of MG53 on insulin signaling and type 2 diabetes mellitus (T2 DM) are still unknown; most are from preclinical studies. Nevertheless, some researchers have argued that it may be a new pathogenic factor, and therapies targeting MG53 may be a new avenue for T2 DM. Our study aims to evaluate the relationship of circulating MG53 levels with the presence of diabetes, diabetic complications, and glycemic control.MethodsWe conducted a case-control study with 107 patients with T2 DM and 105 subjects without insulin resistance-related disease. Concurrent blood samples were used for serum MG53 levels and other biochemical laboratory data. MG53 concentration was measured using Human-MG53, an enzyme-linked immunosorbent assay kit (Cat# CSB-EL024511HU).ResultsWe found no difference in MG53 levels between the diabetic and control groups (p = 0.914). Furthermore, when the subjects were divided into tertiles according to their MG53 levels, we did not find any difference between the groups in terms of the presence of diabetes (p = 0.981). Additionally, no correlation was observed between weight, BMI, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, HbA1c, albumin excretion in the urine, e-GFR levels, and MG53. Finally, MG53 levels were similar between the groups with and without microvascular and macrovascular complications of diabetes.ConclusionOur research finding provides insightful clinical evidence of lack of association between the levels of MG53 and T2 DM or glycemic control, at least in the studied population of Turkeys ethnicity. However, further clinical studies are warranted to establish solid evidence of the link between MG53, insulin resistance and glycemic control in a wider population elsewhere in the world.en_US
dc.description.sponsorshipWe would like to express our deep and sincere gratitude to our research supervisor, Dr. S. Guldiken, Endocrinology and Metabolism.en_US
dc.description.sponsorshipWe would like to express our deep and sincere gratitude to our research supervisor, Dr. S. Guldiken, Endocrinology and Metabolism.en_US
dc.identifier.doi10.1371/journal.pone.0291333
dc.identifier.issn1932-6203
dc.identifier.issue9en_US
dc.identifier.pmid37699054en_US
dc.identifier.scopus2-s2.0-85171119529en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0291333
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25099
dc.identifier.volume18en_US
dc.identifier.wosWOS:001069490400031en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectMiceen_US
dc.titleAssociation of MG53 with presence of type 2 diabetes mellitus, glycemic control, and diabetic complicationsen_US
dc.typeArticleen_US

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