Impact of the Training on the Compliance and Persistence of Weekly Bisphosphonate Treatment in Postmenopausal Osteoporosis: A Randomized Controlled Study

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dc.authoridAkyuz, Gulseren/0000-0002-3724-571X
dc.authoridTUZUN, SANSIN/0000-0002-7705-220X
dc.authorwosidAkyuz, Gulseren/H-9819-2019
dc.authorwosidSarpel, Tunay/D-9438-2018
dc.contributor.authorTuzun, Sansin
dc.contributor.authorAkyuz, Gulseren
dc.contributor.authorEskiyurt, Nurten
dc.contributor.authorMemis, Asuman
dc.contributor.authorKuran, Banu
dc.contributor.authorIcagasioglu, Afitap
dc.contributor.authorSarpel, Tunay
dc.date.accessioned2024-06-12T10:54:45Z
dc.date.available2024-06-12T10:54:45Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractLong-term patient adherence to osteoporosis treatment is poor despite proven efficacy. In this study, we aimed to assess the impact of active patient training on treatment compliance and persistence in patients with postmenopausal osteoporosis. In the present national, multicenter, randomized controlled study, postmenopausal osteoporosis patients (45-75 years) who were on weekly bisphosphonate treatment were randomized to active training (AT) and passive training (PT) groups and followed-up by 4 visits after the initial visit at 3 months interval during 12 months of the treatment. Both groups received a bisphosphonate usage guide and osteoporosis training booklets. Additionally, AT group received four phone calls (at 2nd, 5th, 8th, and 11th months) and participated to four interactive social/training meetings held in groups of 10 patients (at 3rd, 6th, 9th, and 12th months). The primary evaluation criteria were self-reported persistence and compliance to the treatment and the secondary evaluation criteria was quality life of the patients assessed by 41-item Quality of Life European Foundation for Osteoporosis (QUALEFFO-41) questionnaire.. Of 448 patients (mean age 62.4 +/- 7.7 years), 226 were randomized to AT group and 222 were randomized to PT group. Among the study visits, the most common reason for not receiving treatment regularly was forgetfulness (54.9% for visit 2, 44.3% for visit 3, 51.6% for visit 4, and 43.8% for visit 5), the majority of the patients always used their drugs regularly on recommended days and dosages (63.8% for visit 2, 60.9% for visit 3, 72.1% for visit 4, and 70.8% for visit 5), and most of the patients were highly satisfied with the treatment (63.4% for visit 2, 68.9% for visit 3, 72.4% for visit 4, and 65.2% for visit 5) and wanted to continue to the treatment (96.5% for visit 2, 96.5% for visit 3, 96.9% for visit 4, and 94.4% for visit 5). QUALEFFO scores of the patients in visit 1 significantly improved in visit 5 (37.7 +/- 25.4 vs. 34.0 +/- 14.6, p<0.001); however, the difference was not significant between AT and PT groups both in visit 1 and visit 5. In conclusion, in addition to active training, passive training provided at the 1st visit did not improve the persistence and compliance of the patients for bisphosphonate treatment.en_US
dc.description.sponsorshipSanofi-aventis Turkeyen_US
dc.description.sponsorshipSanofi-aventis Turkey provided funding for the study. We would like to thank following researchers for their contribution to the study: (Alphabetical order) U. Akarirmak, E. Akcan, S. Aki, A. Alp, S. Bal, S. Basaran, S. Buyukkaya, A. Cevikol, E. Esen, A. Gurgan, P. Isikci, K. Kaya, T. Kaya, N. Olmez, M. Saridogan, EK Saygi, F. Sahin, C. Tezel, FG Uysal; and to Cagla Isman, MD and Prof. Sule Oktay, MD, PhD. from KAPPA Consultancy Traning Research Ltd, Istanbul who provided editorial support funded by sanofi-aventis Turkey.en_US
dc.identifier.doi10.7150/ijms.5359
dc.identifier.endpage1887en_US
dc.identifier.issn1449-1907
dc.identifier.issue13en_US
dc.identifier.pmid24324365en_US
dc.identifier.scopus2-s2.0-84889566322en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1880en_US
dc.identifier.urihttps://doi.org/10.7150/ijms.5359
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19170
dc.identifier.volume10en_US
dc.identifier.wosWOS:000328163400009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherIvyspring Int Publen_US
dc.relation.ispartofInternational Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBisphosphonatesen_US
dc.subjectOsteoporosisen_US
dc.subjectPatient Educationen_US
dc.subjectMedication Adherenceen_US
dc.subjectOf-Life Questionnaireen_US
dc.subjectVertebral Fracturesen_US
dc.subjectRisedronate Treatmenten_US
dc.subjectEuropean Foundationen_US
dc.subjectAdherenceen_US
dc.subjectWomenen_US
dc.subjectAlendronateen_US
dc.subjectRisken_US
dc.subjectMortalityen_US
dc.subjectTherapyen_US
dc.titleImpact of the Training on the Compliance and Persistence of Weekly Bisphosphonate Treatment in Postmenopausal Osteoporosis: A Randomized Controlled Studyen_US
dc.typeArticleen_US

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