Cortical disinhibition in diabetic patients with neuropathic pain

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dc.contributor.authorTurgut, N.
dc.contributor.authorAltun, B. U.
dc.date.accessioned2024-06-12T11:09:11Z
dc.date.available2024-06-12T11:09:11Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives - Motor cortex disinhibition has a role in the mechanism of neuropathic pain. The duration of the cortical silent period (CSP) is used as a measure of excitability in cortical inhibitory circuits. We investigated cortical disinhibition in diabetic patients with and without neuropathic pain. Materials and methods - We studied diabetic patients with (n = 20) and without (n = 50) neuropathic pain, and control subjects (n = 30). Transcranial magnetic stimulation (TMS) was performed on the right hemisphere at rest, and surface electromyography was recorded from the left first dorsal interosseous muscle for evaluation of motor evoked potential (MEP) latency and amplitude. CSP was recorded from the left FDI, and TMS was then delivered while the subject was performing a voluntary contraction. Results - We showed a low resting motor threshold, a short CSP duration, and a low CSP duration/MEP amplitude ratio in patients with neuropathic pain (P < 0.0001, P < 0.0001, P < 0.0001). Conclusions - Our findings demonstrate that diabetic patients with neuropathic pain have a cortical disinhibition.en_US
dc.identifier.doi10.1111/j.1600-0404.2009.01235.x
dc.identifier.endpage388en_US
dc.identifier.issn0001-6314
dc.identifier.issue6en_US
dc.identifier.pmid19922582en_US
dc.identifier.scopus2-s2.0-72849112695en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage383en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-0404.2009.01235.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22699
dc.identifier.volume120en_US
dc.identifier.wosWOS:000271758800002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwell Publishing, Incen_US
dc.relation.ispartofActa Neurologica Scandinavicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuropathic Painen_US
dc.subjectCortical Silent Perioden_US
dc.subjectDiabetes Mellitusen_US
dc.subjectCortical Disinhibitionen_US
dc.subjectTranscranial Magnetic Stimulationen_US
dc.subjectMotor Cortexen_US
dc.subjectSupraspinal Mechanismsen_US
dc.subjectPeripheral Neuropathyen_US
dc.subjectCingulate Cortexen_US
dc.subjectSilent Perioden_US
dc.subjectDiagnosisen_US
dc.subjectRatsen_US
dc.subjectPrevalenceen_US
dc.subjectAmputationen_US
dc.titleCortical disinhibition in diabetic patients with neuropathic painen_US
dc.typeArticleen_US

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