Protective effects of Urtica dioica L. on experimental testicular ischaemia reperfusion injury in rats

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dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidFidanol Erboga, Zeynep/JVZ-2245-2024
dc.contributor.authorAktas, C.
dc.contributor.authorErboga, M.
dc.contributor.authorErboga, Z. Fidanol
dc.contributor.authorDonmez, Y. Bozdemir
dc.contributor.authorTopcu, B.
dc.contributor.authorGurel, A.
dc.date.accessioned2024-06-12T11:07:16Z
dc.date.available2024-06-12T11:07:16Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this study, it was aimed to examine the effects of Urtica dioica L. (UD) that has antioxidant feature in the experimental testicular I/R model in rats in terms of anti-apoptotic and antioxidative effects. In our study, 24 male rats were divided into three groups: control group, I/R group and I/R+UD (2mgkg(-1)) group. Seminiferous tubule calibre measurement, Johnson score, haematoxylin-eosin staining, proliferative cell nucleus antigen (PCNA) immunohistochemical staining and TUNEL as histopathological have been conducted. The structural deterioration in the testicular on I/R group has reduced after the treatment of UD. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end labelling (TUNEL), and there was a rise in the expression of proliferating cell nuclear antigen (PCNA) in testis tissues of UD-treated rats in the I/R group. The I/R+UD group showed a decrease in malondialdehyde levels and an increase in the activities of superoxide dismutase, catalase and glutathione peroxidase in comparison with the I/R group. It could be concluded that protective effects of UD on the I/R testicles are via reduction of histological damage, apoptosis, oxidative stress and lipid peroxidation.en_US
dc.description.sponsorshipNamik Kemal University Research Center, Tekirdag, Turkey [NKUBAP.00.20.AR.14.11]en_US
dc.description.sponsorshipThis study was supported under Project NKUBAP.00.20.AR.14.11 by the Namik Kemal University Research Center, Tekirdag, Turkey.en_US
dc.identifier.doi10.1111/and.12636
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue4en_US
dc.identifier.pmid27389487en_US
dc.identifier.scopus2-s2.0-84978274910en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.12636
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21978
dc.identifier.volume49en_US
dc.identifier.wosWOS:000398786300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschaemia And Reperfusionen_US
dc.subjectTestis-Apoptosis-Oxidative Stressen_US
dc.subjectUrtica Dioica Len_US
dc.subjectGerm-Cell Apoptosisen_US
dc.subjectOxidative Stressen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectTorsionen_US
dc.subjectTestisen_US
dc.subjectDamageen_US
dc.subjectSpermatogenesisen_US
dc.subjectSupplementationen_US
dc.subjectIndexen_US
dc.subjectSeeden_US
dc.titleProtective effects of Urtica dioica L. on experimental testicular ischaemia reperfusion injury in ratsen_US
dc.typeArticleen_US

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