Formulation of an anti-aging cream containing Alteromonas ferment extract and evaluation of the effect on collagen concentration
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Marmara University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study relates to the Alteromonas ferment extract, a by-product of a marine bacteria, Alteromonas macleodii, is used in anti-aging cream formulation. Alteromonas ferment extract is an innovative anti-pollution ingredient that chelates heavy metals and has non-toxic anionic polysaccharides, which are used as thickening or structuring agent in tissue engineering, wound management or drug delivery applications. Aging is a physiological process, it is undesirable especially on the skin. Aging leads to weakening of facial muscles and loss of subcutaneous fat and skin laxity, along with wrinkles, prominent lines and sagging skin. Changes in collagen play an important role in reducing skin elasticity. In this case, fibroblast decreases, matrix metalloproteinase increases (responsible for collagen breakdown), and glycosaminoglycans decrease. The objective of the study was to evaluate effects of the anti-aging cosmetic face cream including Alteromonas ferment extract on human dermal fibroblast cells. The outcomes of the characterization analysis have indicated the development of a successful cream formulation with optimum characteristics. No microbial growth was observed. Given the results obtained in the tested conditions, the anti-aging cream is not cytotoxic against fibroblasts 0.5% or less concentration. The dilutions of 0.1% and 0.2% were chosen for evaluation of collagen concentration, because they were the most appropriate concentrations in terms of solubility and lack of cytotoxicity. The treatment with anti-aging cream formulation at 0.1% and 0.2% increased collagen synthesis 57% and 67%, respectively in cell culture. © 2023 Marmara University Press.
Açıklama
Anahtar Kelimeler
Alteromonas Ferment Extract; Anionic Polysaccharides; Anti-Aging Cream; Collagen Synthesis; Skin Aging, Chelate; Collagen; Glycosaminoglycan; Heavy Metal; Matrix Metalloproteinase; Polysaccharide; Aging; Alteromonas; Article; Bacterium Culture; Cell Culture; Collagen Synthesis; Controlled Study; Cream; Cutaneous Parameters; Cutis Laxa; Cytotoxicity; Dilution; Drug Delivery System; Drug Formulation; Elasticity; Face Muscle; Fibroblast; Human; Human Cell; Marine Bacterium; Microbial Growth; Nonhuman; Physiological Process; Protein Function; Sagging Skin; Subcutaneous Fat; Tissue Engineering; Wound; Wrinkle
Kaynak
Journal of Research in Pharmacy
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
27
Sayı
2
