In vitro effects of prostaglandin E1, prostaglandin I2 and papaverine on internal thoracic artery graft

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dc.authoridSunar, Hasan/0000-0002-1276-8549
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authoridYuksel, Volkan/0000-0001-9518-2588
dc.authorwosidSunar, Hasan/A-8685-2018
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorMisirlioglu, Ganime
dc.contributor.authorHuseyin, Serhat
dc.contributor.authorYuksel, Volkan
dc.contributor.authorGuclu, Orkut
dc.contributor.authorKaradag, Hakan
dc.contributor.authorCanbaz, Suat
dc.contributor.authorEge, Turan
dc.date.accessioned2024-06-12T10:58:35Z
dc.date.available2024-06-12T10:58:35Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: This study aims to investigate the effects of prostaglandin E1, prostaglandin I2, and papaverine on internal thoracic artery grafts which are used during coronary artery bypass graft operations. Methods: Ten patients (9 males, 1 female; mean age 53.7 years; range 46 to 68 years) who were operated in our clinic between March 2013 and September 2013 were enrolled in the study. Dose-dependent effects of prostaglandin E1 and prostaglandin I2 on internal thoracic artery at a concentration interval of 10(-9) M-10(-2.5) M were observed. Results: While prostaglandin I2 had stronger relaxation response than prostaglandin E1 on internal thoracic artery graft, papaverine had the strongest relaxation response. Conclusion: Prostaglandin E1 and prostaglandin I2, which are used in the treatment of many aterosclerotic cardiovascular and peripheral artery diseases, may prevent vasoconstriction in internal thoracic artery grafts. Further clinical studies are required regarding decreasing perioperative mortality and morbidity by increasing graft patency.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2015.10990
dc.identifier.endpage466en_US
dc.identifier.issn1301-5680
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84936165968en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage463en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2015.10990
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20112
dc.identifier.volume23en_US
dc.identifier.wosWOS:000357842000007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal Of Thoracic And Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Artery Bypass Graft Operationen_US
dc.subjectInternal Thoracic Arteryen_US
dc.subjectOrgan Bathen_US
dc.subjectPapaverineen_US
dc.subjectProstaglandin E1en_US
dc.subjectProstaglandin I2en_US
dc.subjectSaphenous Veinen_US
dc.subjectMammary-Arteryen_US
dc.subjectVasospasmen_US
dc.subjectSerialen_US
dc.subjectFlowen_US
dc.titleIn vitro effects of prostaglandin E1, prostaglandin I2 and papaverine on internal thoracic artery graften_US
dc.typeArticleen_US

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