THE ROLE OF IONIZING RADIATION ON OVULATION RATE AND OOCYTE MORPHOLOGY IN MOUSE

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dc.contributor.authorSapmaz-Metin, Melike
dc.contributor.authorKanter, M.
dc.contributor.authorUzal, C.
dc.date.accessioned2024-06-12T11:04:00Z
dc.date.available2024-06-12T11:04:00Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated the effects of ionizing radiation on maturation ability and radiosensitivity of oocytes enclosed in preantral and antral follicles. Balb/c female mice received total body single dose gamma radiation (7.2 Gy) at the diestrous to proestrous transition period. In the first experiment, spontaneously ovulated oocytes were collected from irradiated animals. In the second experiment, irradiated animals were allowed to superovulate to assess the ovarian function. The spontaneous ovulation rate of the follicles exposed at antral stage was significantly lower than the sham-irradiated mice (p < 0.01), and most of the oocytes were found at the metaphase I stage. Oocyte morphology and the ovulation rate of the follicles exposed at preantral stage were similar to the sham-irradiated group. Minimal morphological abnormalities were observed in the oocytes and the polar body as well. The superovulation response of all the irradiated animals was lower than the respective control animals. The superovulation rate was significantly lower in the first ovulation after irradiation (p < 0.01). In conclusion, our findings indicate that total body gamma irradiation, on a basis of estrous cycle stages, leads to ovulation failure in the antral stage while causes abnormal oocyte morphology in the preantral stage follicles in mice.en_US
dc.description.sponsorshipTrakya University Research Center, Edirne, Turkey [816]en_US
dc.description.sponsorshipThis study received financial support from Trakya University Research Center (project no: 816), Edirne, Turkey. The authors acknowledge the contribution of Dr. Imran Kurt Omurlu in the statistical analysis of this study.en_US
dc.identifier.doi10.1556/ABiol.65.2014.1.3
dc.identifier.endpage37en_US
dc.identifier.issn0236-5383
dc.identifier.issn1588-256X
dc.identifier.issue1en_US
dc.identifier.pmid24561892en_US
dc.identifier.scopus2-s2.0-84896824764en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage27en_US
dc.identifier.urihttps://doi.org/10.1556/ABiol.65.2014.1.3
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21875
dc.identifier.volume65en_US
dc.identifier.wosWOS:000332009000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Zrten_US
dc.relation.ispartofActa Biologica Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIonizing Radiationen_US
dc.subjectOvulation Rateen_US
dc.subjectOocyteen_US
dc.subjectEstrous Cycleen_US
dc.subjectMiceen_US
dc.subjectFertilization Rateen_US
dc.subjectOvarian-Folliclesen_US
dc.subjectEmbryo Qualityen_US
dc.subjectIrradiationen_US
dc.subjectMaturationen_US
dc.subjectAtresiaen_US
dc.subjectSensitivityen_US
dc.subjectCycleen_US
dc.titleTHE ROLE OF IONIZING RADIATION ON OVULATION RATE AND OOCYTE MORPHOLOGY IN MOUSEen_US
dc.typeArticleen_US

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