Superoxide dismutase activity and the effects of NBQX and CPP on lipid peroxidation in experimental spinal cord injury

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dc.authoridKiris, Talat/0000-0002-2985-3758
dc.authorwosidKiris, Talat/AAP-4665-2020
dc.contributor.authorGörgülü, A
dc.contributor.authorKiris, T
dc.contributor.authorÜnal, F
dc.contributor.authorTurkoglu, Ü
dc.contributor.authorKüçük, M
dc.contributor.authorÇobanoglu, S
dc.date.accessioned2024-06-12T10:51:27Z
dc.date.available2024-06-12T10:51:27Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe endogenous activity of the neuroprotective enzyme superoxide dismutase (SOD) and the amount of lipid peroxidation in the early phase of experimental spinal cord injury, together with the effects of N-methyl-D-aspartate (NMDA) antagonist CPP and non-NMDA antagonist NBQX on lipid peroxidation were evaluated. The clip compression model was used for the production of a standardized spinal cord trauma. SOD activity and malondialdehyde (MDA) levels - as an indicator of lipid peroxidation - were determined in the injured segment of the spinal cord 30 and 60 min after injury. SOD activity did not change in this period, whereas MDA levels at 30 and 60 min after trauma were significantly elevated. Intrathecal administration of CPP or NBQX 15 min after injury produced statistically significant reductions in MDA elevation 60 min after injury. NBQX was found to be more effective than CPP. These results demonstrated that intrathecal local application of excitatory amino acid receptor antagonists can protect the spinal cord from secondary damage caused by the generation of lipid peroxides in experimental spinal cord injury.en_US
dc.identifier.doi10.1007/s004330050126
dc.identifier.endpage293en_US
dc.identifier.issn0300-9130
dc.identifier.issue5en_US
dc.identifier.pmid10815757en_US
dc.identifier.scopus2-s2.0-0034093311en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage285en_US
dc.identifier.urihttps://doi.org/10.1007/s004330050126
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18374
dc.identifier.volume199en_US
dc.identifier.wosWOS:000086934000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofResearch In Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAMPA/Kainateen_US
dc.subjectNMDAen_US
dc.subjectLipid Peroxidationen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectTime-Level Relationshipen_US
dc.subjectExcitatory Amino-Acidsen_US
dc.subjectFunctional Deficitsen_US
dc.subjectTraumaen_US
dc.subjectIschemiaen_US
dc.subjectRaten_US
dc.subjectReceptorsen_US
dc.subjectAntagonisten_US
dc.subjectRabbiten_US
dc.subjectBrainen_US
dc.titleSuperoxide dismutase activity and the effects of NBQX and CPP on lipid peroxidation in experimental spinal cord injuryen_US
dc.typeArticleen_US

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