The effect of glucose-insulin-potassium solution on ventricular late potentials and heart rate variability in acute myocardial infarction

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dc.contributor.authorUlgen, MS
dc.contributor.authorAlan, S
dc.contributor.authorAkdemir, O
dc.contributor.authorToprak, N
dc.date.accessioned2024-06-12T10:50:35Z
dc.date.available2024-06-12T10:50:35Z
dc.date.issued2001
dc.departmentTrakya Üniversitesien_US
dc.description22nd Congress of the European Society of Cardiology -- AUG 26-31, 2000 -- AMSTERDAM, NETHERLANDSen_US
dc.description.abstractBackground Blunted heart rate variability (HRV) and presence of ventricular late potentials (VLPs) are known to correlate with an increased risk of ventricular tachycardia and sudden cardiac death in acute myocardial infarction (AMI), In the present study, we investigated the effect of glucose-insulin-potassium (GIK) solution on the VLPs and HRV in AMI. Methods Seventy-two consecutive patients with first Q wave AMI were randomized to GIK solution and placebo. HRV analysis and ambulatory electrocardiographic recordings were taken in all patients between 24 and 48 h. Sub-maximal exercise testing and echocardiography were performed and signal-averaged electrocardiography (SAECG) was recorded before discharge. Results Total filtered QRS duration (FORS: 102 +/- 7 versus 108 +/- 11 ms; P < 0.05), low-amplitude signal (LAS: 25 +/- 8 versus 32 +/- 11 ms; P < 0.01) and frequency of VLPs (21 versus 45%; P < 0.05) were found to be significantly lower while root-mean-square voltage of the terminal 40 ms. of QRS (RMS-40: 45 +/- 18 versus 36 +/- 20 V; P < 0.05), and left ventricular ejection fraction (EF: 55 +/- 6 versus 48 +/- 7; P < 0.05) were significantly higher in the GIK group when compared to placebo. During the hospital period, the presence and frequency of post-myocardial infarction angina were significantly lower in the GIK group (15 versus 29%, P < 0.05), whereas an insignificant decrease in frequency of ventricular arrhythmias was observed in these patients. On HRV analysis, there was no significant difference between two groups in either time domain (SID, SDNN, RMS-SD) or frequency domain (HF, LF, LF/HF ratio) parameters. Conclusion GIK solution may be beneficial to VLPs, ischaemic events, and left ventricular systolic performance in the early period of AMI. This therapy has no significant effect on HRV in AM] patients. Coron Artery Dis 12:507-512 (C) 2001 Lippincott Williams &Lippincott Wilkins.en_US
dc.description.sponsorshipEuropean Soc Cardiolen_US
dc.identifier.doi10.1097/00019501-200109000-00010
dc.identifier.endpage512en_US
dc.identifier.issn0954-6928
dc.identifier.issue6en_US
dc.identifier.pmid11696690en_US
dc.identifier.scopus2-s2.0-0034774606en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage507en_US
dc.identifier.urihttps://doi.org/10.1097/00019501-200109000-00010
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18059
dc.identifier.volume12en_US
dc.identifier.wosWOS:000171509800010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Myocardial Infarctionen_US
dc.subjectGlucose-Insulin-Potassiumen_US
dc.subjectHeart Rate Variabilityen_US
dc.subjectLate Potentialsen_US
dc.subjectSignal-Averaged Electrocardiogramen_US
dc.subjectThrombolytic Therapyen_US
dc.subjectRisk Stratificationen_US
dc.subjectArrhythmiasen_US
dc.subjectAngioplastyen_US
dc.subjectIschemiaen_US
dc.subjectPerioden_US
dc.subjectDeathen_US
dc.titleThe effect of glucose-insulin-potassium solution on ventricular late potentials and heart rate variability in acute myocardial infarctionen_US
dc.typeConference Objecten_US

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