Vaccination status of COVID-19 patients followed up in the ICU in a country with heterologous vaccination policy: A multicenter national study in Turkey

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dc.authoridyildirim, suleyman/0000-0001-9856-3431
dc.authoridsarı, ali/0000-0002-0181-7202
dc.authoridyakar, mehmet nuri/0000-0002-3542-3906
dc.authoridAlbayrak, Tuna/0000-0002-0222-9277
dc.authoridKirakli, Cenk/0000-0001-6013-7330
dc.authoridErdal Donmez, Gul/0000-0002-8377-1876
dc.authoridYILMAZ, BARIS/0000-0003-4811-4907
dc.authorwosidYılmaz, Barış/JMP-3341-2023
dc.authorwosidyildirim, suleyman/ITW-0052-2023
dc.authorwosidsarı, ali/HHD-1791-2022
dc.authorwosidyakar, mehmet nuri/AAE-3986-2020
dc.authorwosidYilmaz, Huseyin Oguz/B-1093-2015
dc.authorwosidAlbayrak, Tuna/JMB-3161-2023
dc.authorwosidKirakli, Cenk/AAE-2202-2020
dc.contributor.authorYildirim, Suleyman
dc.contributor.authorErkoyun, Erdem
dc.contributor.authorAlpdog, Ozcan
dc.contributor.authorYilmaz, Huseyin Oguz
dc.contributor.authorYilmaz, Baris
dc.contributor.authorDonmez, Gul Erdal
dc.contributor.authorSaritas, Aykut
dc.date.accessioned2024-06-12T10:58:44Z
dc.date.available2024-06-12T10:58:44Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-2) prevents the development of serious diseases has been shown in many studies. However, the effect of vaccination on outcomes in COVID-19 patients requiring intensive care is not clear.Methods: This is a retrospective multicenter study conducted in 17 intensive care unit (ICU) in Turkey between January 1, 2021, and December 31, 2021. Patients aged 18 years and older who were diagnosed with COVID-19 and followed in ICU were included in the study. Patients who have never been vaccinated and patients who have been vaccinated with a single dose were considered unvaccinated. Logistic regression models were fit for the two outcomes (28-day mortality and in-hospital mortality).Results: A total of 2968 patients were included final analysis. The most of patients followed in the ICU during the study period were unvaccinated (58.5%). Vaccinated patients were older, had higher Charlson comorbidity index (CCI), and had higher APACHE-2 scores than unvaccinated patients. Risk for 28-day mortality and in-hospital mortality was similar in across the year both vaccinated and unvaccinated patients. However, risk for in-hospital mortality and 28-day mortality was higher in the unvaccinated patients in quarter 4 adjusted for gender and CCI (OR: 1.45, 95% CI: 1.06-1.99 and OR: 1.42, 95% CI: 1.03-1.96, respectively) compared to the vaccinated group.Conclusion: Despite effective vaccination, fully vaccinated patients may be admitted to ICU because of disease severity. Unvaccinated patients were younger and had fewer comorbid conditions. Unvaccinated patients have an increased risk of 28-day mortality when adjusted for gender and CCI.en_US
dc.identifier.doi10.1016/j.jiac.2023.06.012
dc.identifier.endpage964en_US
dc.identifier.issn1341-321X
dc.identifier.issn1437-7780
dc.identifier.issue10en_US
dc.identifier.pmid37343924en_US
dc.identifier.scopus2-s2.0-85162213490en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage959en_US
dc.identifier.urihttps://doi.org/10.1016/j.jiac.2023.06.012
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20179
dc.identifier.volume29en_US
dc.identifier.wosWOS:001074323500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Infection And Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectIntensive Care Uniten_US
dc.subjectMortalityen_US
dc.subjectVaccinationen_US
dc.subjectOutcomesen_US
dc.titleVaccination status of COVID-19 patients followed up in the ICU in a country with heterologous vaccination policy: A multicenter national study in Turkeyen_US
dc.typeArticleen_US

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