Detection of Epstein Barr virus in Hodgkin's disease in Trakya Region of Turkey; By in situ hybridization

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dc.authorscopusid6505922818
dc.authorscopusid6603302570
dc.authorscopusid7004457653
dc.authorscopusid9537275000
dc.authorscopusid6602879762
dc.contributor.authorÖzdil A.
dc.contributor.authorDo?anay L.
dc.contributor.authorDemir M.
dc.contributor.authorÖz Puyan F.
dc.contributor.authorBilgi S.
dc.date.accessioned2024-06-12T10:28:46Z
dc.date.available2024-06-12T10:28:46Z
dc.date.issued2002
dc.description.abstractThe relation of Epstein-Barr virus (EBV) and Hodgkin's disease (HD) has been suggested by serologic, epidemiological and molecular biologic studies. According to these studies the incidence of EBV in HD is high. In the present study, the EBV association with HD in Trakya Region of Turkey was investigated. We investigated the presence of EBV in 44 cases of HD. Fluorescein-labelled antisense EBV (EBER-RNA) was performed by in situ hybridization. There were 28 males and 16 females, with a mean age of 40 years (range 4-80 years). Histological subtypes included nodular sclerosis Hodgkin's disease (NSHD) in 18 (40.9%), mixed cellularity (MCHD) in 16 (36.4%), lymphocyte predominance (LPHD) in 7 (15.9%), and lymphocyte depletion (LDHD) in 3 (6.8%). EBV was expressed in 30 cases (68.2%). High EBV association was found with mixed cellularity 75% and nodular sclerosis 72.2%. In lymphocyte predominance and in lymphocyte depletion cases the EBV positivity was 57.1% and 33.3%, respectively. All of 7 cases, younger than 15 years old, were positive for EBV. HD in Trakya Region showed a high association with EBV as in developing countries. Our findings suggest that EBV plays an important role in the pathogenesis of HD in Turkey.en_US
dc.identifier.endpage464en_US
dc.identifier.issn1300-7777
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-0036441724en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage461en_US
dc.identifier.trdizinid19694en_US
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/19694
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17412
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Haematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpstein-Barr Virus; Hodgkin's Disease; In Situ Hybridizationen_US
dc.subjectComplementary Rna; Virus Rna; Adolescent; Adult; Aged; Article; Child; Clinical Article; Controlled Study; Correlation Analysis; Developing Country; Disease Association; Disease Classification; Epstein Barr Virus; Female; Fluorescence Analysis; Geographic Distribution; Histology; Hodgkin Disease; Human; In Situ Hybridization; Incidence; Lymphocyte Count; Lymphocyte Depletion; Male; Mixed Cell Lymphoma; Nonhuman; Pathogenesis; Statistical Significance; Turkey (Republic); Virus Detectionen_US
dc.titleDetection of Epstein Barr virus in Hodgkin's disease in Trakya Region of Turkey; By in situ hybridizationen_US
dc.typeArticleen_US

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