Effects of halothane, isoflurane, and sevoflurane on lipid peroxidation following experimental closed head trauma in rats

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dc.contributor.authorYurdakoc, A.
dc.contributor.authorGunday, I.
dc.contributor.authorMemis, D.
dc.date.accessioned2024-06-12T11:16:41Z
dc.date.available2024-06-12T11:16:41Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: In a rat closed head trauma model we examined both the time course of lipid peroxidation and the effects of halothane, isoflurane, and sevoflurane on it by analysis of malondialdehyde (MDA) formation. Methods: Animals were divided randomly into five groups: sham-operated (SO), n=18; control-closed head trauma to left frontal pole, n=18; closed head trauma model+halothane, n=18; closed head trauma model+isoflurane, n=18; and closed head trauma model+sevoflurane, n=18. Halothane, isoflurane, or sevoflurane were applied 15 min after trauma for 30 min. Rats were euthanized 1,3, and 5 h after the inhalation agents. Brain tissue samples were taken 5 mm from the left and right frontal poles. MDA was considered to reflect the degree of lipid peroxidation. Results: MDA concentrations were greater in the control, halothane, sevoflurane, and isoflurane groups than in SO animals (P < 0.001). No statistical difference between the hemispheres was found between the halothane, isoflurane, or sevoflurane groups, but MDA levels were lower with isoflurane than in the halothane, sevoflurane, and control groups at 1, 3, and 5 h (P < 0.001). MDA levels were higher as compared with the halothane and sevoflurane groups at 1 h but not at 3 or 5 h (P < 0.001). Conclusion: MDA levels with the isoflurane group were lower than in the other trauma groups, which suggest that isoflurane, given after closed head trauma, might be protective against lipid peroxidation of cerebral injury.en_US
dc.identifier.doi10.1111/j.1399-6576.2008.01635.x
dc.identifier.endpage663en_US
dc.identifier.issn0001-5172
dc.identifier.issn1399-6576
dc.identifier.issue5en_US
dc.identifier.pmid18419720en_US
dc.identifier.scopus2-s2.0-42249115674en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage658en_US
dc.identifier.urihttps://doi.org/10.1111/j.1399-6576.2008.01635.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24397
dc.identifier.volume52en_US
dc.identifier.wosWOS:000255040300014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofActa Anaesthesiologica Scandinavicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTraumatic Brain Injuryen_US
dc.subjectHalothaneen_US
dc.subjectIsofluraneen_US
dc.subjectSevofluraneen_US
dc.subjectMalondialdehydeen_US
dc.subjectRatsen_US
dc.subjectIncomplete Cerebral-Ischemiaen_US
dc.subjectD-Aspartate Receptoren_US
dc.subjectBrain-Injuryen_US
dc.subjectVolatile Anestheticsen_US
dc.subjectBlood-Flowen_US
dc.subjectIn-Vitroen_US
dc.subjectGlutamateen_US
dc.subjectFentanylen_US
dc.subjectChannelsen_US
dc.subjectNeuroprotectionen_US
dc.titleEffects of halothane, isoflurane, and sevoflurane on lipid peroxidation following experimental closed head trauma in ratsen_US
dc.typeArticleen_US

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