Idiopathic thrombocytopenic purpura in children - A single centre experience
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The objective of the study was to review retrospectively our institutional experience of childhood idiopathic thrombocytopenic purpura (ITP). Medical records of all children diagnosed with ITP and treated in our centre between ages of 2 months to 16 years from January 1999 to December 2004 were reviewed. There were 28 were girls and 26 boys with a F/M ratio of 1.07, and a mean age (SD) of 54 children was 6.2 (2.1) years The majority of our patients had only mild and moderate bleeding symptoms and no intracranial haemorrhage occurred. A preceding viral infection history was noted in 57.4%. Mean platelet count at presentation was 12.2×109/l, mean platelet count of cases with wet purpura was 6.8×109/l which was significantly lower (P<0.001). Only one patient required erythrocyte transfusion and none of the patients received platelet transfusion at the admission time. Initial management consisted of no drug treatment in 7.4%, IVIG in 76.2%, corticosteroids in 14.8% or both in 11.1% patients. Three children received anti-D immune globulin, 3 cases unresponsive to various treatments were treated with cyclosporine A. Four cases had a recurrence within 6 months and had a favourable outcome. A total of 74% had acute ITP, whereas 26% were classified as chronic ITP. Splenectomy was performed in 2 patients who had chronic ITP, 1 child had a good response the other one was unresponsive. In our chronic ITP cases, 64.3% were younger than 10 years of age, whereas 35.7% were older than 10 years at presentation. However, 22% of children < 10 years had a chronic form whereas 38.4% of children > 10 years developed chronic ITP. In conclusion, our results were in accordance with the literature. Copyright © Hellenic Society of Haematology.
Açıklama
Anahtar Kelimeler
Children; Idiopathic Thrombocytopenic Purpura; Treatment, Corticosteroid; Cyclosporin A; Immunoglobulin; Rhesus D Antibody; Bleeding; Brain Hemorrhage; Childhood Disease; Disease Severity; Erythrocyte Transfusion; Human; Idiopathic Thrombocytopenic Purpura; Recurrent Disease; Review; Thrombocyte Count; Treatment Outcome; Virus Infection
Kaynak
HAEMA
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
9
Sayı
3
