Akinetic mutism due to diphenylhydantoin toxicity
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Date
1997
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Turkish J Pediatrics
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Akinetic mutism (AM) is a rare, specific, unconscious state. An AM patient seems to be awake, lacks mental activity, is unable to speak, and does not respond to any environmental stimulus. Cyclical sleep and awake states are maintained, and incontinence is present. Various factors such as tumor, vascular events, drug use and radiotherapy are responsible for the development of AM. A 12-year-old epileptic patient displayed AM and diphenylhydantoin toxicity (DPH). She seemed awake, was unable to speak or to understand, and had no movements with either spontaneous or noxious stimuli. Her serum DPH level was greater than 40 mu g/ml. Magnetic resonance imaging (MRI) showed mild cerebellar atrophy. All known causes of AM were excluded. The AM state in this patient was considered to be due to toxic DPH levels, She regained her motor and mental activity within two months after carbamazepine was administered to replace DPH. She was symptom-free when examined at the two-year follow-up. No similar adverse effect of DPH has been reported to date.
Description
Keywords
Diphenylhydantoin, Akinetic Mutism, Adverse Effect
Journal or Series
Turkish Journal Of Pediatrics
WoS Q Value
N/A
Scopus Q Value
Q3
Volume
39
Issue
3
