Empact syndrome: Case report
Küçük Resim Yok
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Intracranial malignancies often complicated by seizure activity. For this reason, phenytoin is typically employed as a prophylactic anticonvulsant. However, severe cutaneous adverse effects may occur in these patients. Especially in patients who received cranial radiotherapy, starting from the radiation field to the whole body can be seen erythema multiforme-like lesions. Recently, in the patients with brain metastases, using phenytoin and taking cranial radiation developing erythema multiforme major is defined as EMPACT (Erythema Multiforme associated with Phenitoin And Cranial radiation Therapy) syndrome. So far, in the national and international medical literature, a few case reports about this new syndrome have been presented. The pathogenesis of EMPACT syndrome has not been completely understood but a combination of metabolic and immunologic mechanisms may be involved. In this article, we also present the case of a 53-year-old female with EMPACT syndrome. Here, during cranial radiotherapy, especially before prophylactic anticonvulsant therapy utilizing phenytoin, the benefits of patient-focused thinking and the importance of multidisciplinary approach are asked to be highlighted. Clinical findings, pathogenesis, differential diagnosis and treatment of the disease were also discussed with new information. Copyright © 2010 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Erythema Multiforme; Phenytoin; Radiotherapy, Phenytoin; Adult; Article; Brain Cancer; Brain Metastasis; Case Report; Differential Diagnosis; Disease Severity; Empact Syndrome; Erythema Multiforme; Female; Human; Pathogenesis; Radiation Field; Seizure; Whole Body Scintiscanning
Kaynak
Turkiye Klinikleri Dermatoloji
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
20
Sayı
1
