Variant Analysis of the Sirtuin (SIRT1) Gene in Multiple Sclerosis

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dc.authoridDursun, Ahmet/0000-0002-7625-837X
dc.authorwosidDursun, Ahmet/HGU-7580-2022
dc.contributor.authorEdgunlu, Tuba Gokdogan
dc.contributor.authorCelik, Sevim Karakas
dc.contributor.authorEmre, Ufuk
dc.contributor.authorUnal, Aysun Eroglu
dc.contributor.authorDursun, Ahmet
dc.date.accessioned2024-06-12T10:54:04Z
dc.date.available2024-06-12T10:54:04Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Multiple sclerosis (MS) is an inflammatory demyelinating disease affecting the central nervous system. Although the exact pathogenesis of MS is unknown, it is generally considered to be an autoimmune disease, with numerous genetic and environmental factors determining disease susceptibility and severity. Sirtuin 1 (SIRT1) is a neuroprotective enzyme in MS patients. The aim of our study was to investigate the relationship between a genetic variant of SIRT1 and MS. Design: Controlled prospective study Setting: Department of Neurology, Bulent Ecevit University Medical Faculty, Zonguldak, Turkey Subjects and Methods: We determined SIRT1 genotypes by polymerase chain reaction (PCR) and confronting two-pair primers (CTPP) methods in 93 MS patients and 100 healthy controls Intervention: For genetic analysis, 5 ml of venous blood was drawn from each patient into tubes containing EDTA Main Outcome Measures: SIRT1 gene polymorphisms and recorded expanded disability status scale (EDSS) for MS patients Results: We found a significant difference between the rs2273773 polymorphism of the SIRT1 gene of MS and the control group (p = 0.011). We also found an association between MS disease and the haplotypes of rs7895833, rs7069102 and rs2273773 polymorphisms. Conclusion: We have shown that rs2273773 polymorphism of the SIRT1 gene might be a risk factor for MS disease in the Turkish population. Also, additional studies are needed to clarify the role of the SIRT1 gene in the pathogenesis of MS disease.en_US
dc.identifier.endpage318en_US
dc.identifier.issn0023-5776
dc.identifier.issue4en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18893
dc.identifier.volume45en_US
dc.identifier.wosWOS:000327752700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKuwait Medical Assocen_US
dc.relation.ispartofKuwait Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoimmune Diseaseen_US
dc.subjectNeurodegenerative Diseaseen_US
dc.subjectOptic Neuritisen_US
dc.subjectProtein Sir2en_US
dc.subjectStressen_US
dc.subjectDeacetylaseen_US
dc.subjectInflammationen_US
dc.subjectDiseasesen_US
dc.subjectTargetsen_US
dc.subjectLesionsen_US
dc.subjectInjuryen_US
dc.subjectP53en_US
dc.titleVariant Analysis of the Sirtuin (SIRT1) Gene in Multiple Sclerosisen_US
dc.typeArticleen_US

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