Investigation of the relationship between MTHFR, IRS and CALCA gene polymorphisms and development of diabetic nephropathy in patients with type 2 diabetes mellitus

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dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.contributor.authorAy, Arzu
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorSipahi, Tammam
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorUstundag, Sedat
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:59:42Z
dc.date.available2024-06-12T10:59:42Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the relationship between MTHFR, IRS and CALCA gene polymorphisms and development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (DM). Our study included 93 patients with type 2 DM diagnosed as having nephropathy and 95 controls diagnosed with type 2 DM without development of DN. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to determine the genotype distributions of MTHFR, IRS and CALCA gene polymorphisms. The results showed no statistically significant difference between DN patients and type 2 DM controls in terms of genotype distributions of MTHFR (C677T, A1298C), IRS (IRS-1 Gly972Arg, IRS-2 Gly1057Asp) and CALCA T692C gene polymorphisms (p > 0.05). However, in terms of allele frequencies for the MTHFR A1298C gene, the frequency of the C allele was significantly higher in the DN patients compared to the controls (p < 0.05). In the IRS-2 Gly1057Asp gene polymorphism, the G allele frequency was significantly higher in the DN patients than in the type 2 DM controls (p < 0.05). In the DN group, the individuals with one or less mutant alleles were significantly more than in the control group in terms of the IRS-2 Gly1057Asp gene polymorphism (p < 0.05). The C allele frequency for the MTHFR A1298C gene polymorphism and the G allele frequency for the IRS-2 Gly1057Asp gene polymorphism were indicated to be potential a genetic risk factor for the development of DN in patients with type 2 DM who developed DN.en_US
dc.identifier.doi10.1080/13102818.2018.1485514
dc.identifier.endpage1265en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85062854736en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1257en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2018.1485514
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20550
dc.identifier.volume32en_US
dc.identifier.wosWOS:000461045700021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDNen_US
dc.subjectMTHFRen_US
dc.subjectIRSen_US
dc.subjectCALCAen_US
dc.subjectPCRen_US
dc.subjectRFLPen_US
dc.subjectMethylenetetrahydrofolate Reductase Geneen_US
dc.subjectReceptor Substrate-2 Geneen_US
dc.subjectAmino-Acid Polymorphismen_US
dc.subjectA1298c Polymorphismsen_US
dc.subjectRisk-Factoren_US
dc.subjectInsulin-Resistanceen_US
dc.subjectSkeletal-Muscleen_US
dc.subjectCommon Mutationen_US
dc.subjectKinase-Ben_US
dc.subjectC677ten_US
dc.titleInvestigation of the relationship between MTHFR, IRS and CALCA gene polymorphisms and development of diabetic nephropathy in patients with type 2 diabetes mellitusen_US
dc.typeArticleen_US

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