Sigaranın lipid profili ve metabolik yapıya etkisi
Yükleniyor...
Dosyalar
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Sigara kullanımının metabolik yapıyı bozarak aterosklerotik hastalık gelişim riskini artırdığı öne sürülmüştür. Ancak, günümüze kadar gerçekleştirilen çalışmalarda, diyabet, hipertansiyon gibi eşlik eden hastalıklar ve ateroskleroz gelişimini etkileyen diğer risk faktörlerinin varlığının genellikle dışlamamış olması, sigaranın metabolik yapı-ateroskleroz üzerine bağımsız etkilerini belirlemeyi zorlaştırmaktadır. Bu nedenle, bilinen herhangi bir hastalığı olmayan sağlıklı erkek gönüllülerde sigara kullanımının metabolik yapı, renin-anjiotensin sistemi, inflamasyon göstergeleri ve nefron fonksiyonuna etkisi araştırmayı amaçladık. Sigara içen olgularımızın bel çevresi (p=0.017), VKİ (p=0.035), AKŞ (p=0.007), ürik asit (p=0.013), albumin (p=0.003), kreatinin (p=0.007) düzeyleri anlamlı düşük; GFH (p=0.013), lökosit (p<0.001) ve ortalama eritrosit hacimleri (p<0.001) yüksek bulundu. On paket/yıldan daha fazla sigara içen olgularımıza göre daha fazla sigara içen olgularımızın albumin düzeyleri (p<0.05) düşük, nabız sayısı (p<0.005), fibrinojen (p<0.005) ve hs-CRP (p<0.005) düzeyleri yüksek bulundu. Günde 20 adetten daha az sigara içen olgularımıza göre daha fazla sigara içen olgularımızın anjiotensin II (p<0.005) ve lökosit sayıları (p<0.05) daha yüksek bulundu. Paket yıl olarak sigara tüketim miktarı ile fibrinojen (r=0.341), total kolesterol (r=0.218), LDL-kolesterol düzeyleri (r=0.213) pozitif; albumin(r=-0.213) ve GFH (r=-0.191) düzeyleri negatif ilişkili bulundu. Sonuçlarımız, bilinen bir hastalığı olmayan, yaş ortalamaları 34 yıl gibi oldukça genç erkek olgularımızda, sigara kullanımın, paket/yıl olarak tüketilen sigara miktarı ve günlük tüketilen sigara sayısı ile ilişkili olarak lipid profilini aterojenik yönde bozduğunu, nutrisyonel parametreleri olumsuz etkilediğini, inflamatuar göstergeleri ve anjiotensin II düzeylerini artırdığını, nefron fonksiyonlarını bozduğunu ortaya koymaktadır.
Abstract
It has been suggested that smoking increases the risk of atherosclerosis by disturbing the metabolism. Comorbidities like diabetes and hypertansion and other risk factors for atherosclerosis can’t be excluded in recent studies. Thus it makes difficult to define independent effects of smoking on metabolic structure-atherosclerosis. For this reason, we proposed to search about the effects of cigarette smoking on metabolic structure, renin-angiotensin system, inflammatory markers and nephron function in healthy men. In smoking cases waist circumference (p=0.017), BMI (p=0.035), fasting blood glucose (p=0.007), uric acid (p=0.013), albumin (p=0,003), creatinin (p=0,007) levels were found significantly low; GFR (p=0,013), leukocyte (p<0,001) and mean erythrocyte volume (p<0,001) levels were found significantly high. When we compared smokers less than ten pocket-years and more than ten pocket-years we found that in second group of cases albumin levels were low (p <0.05) and heart rate (p<0.005) , fibrinogen (p<0.005) and hs-CRP (p<0.005) levels were significantly high .In cases smoking more than twenty cigarettes daily comparing to cases smoking less than twenty cigarettes daily angiotensin II (p<0,005), leukocyte (p<0,05) levels were found significantly high. Cigarette smoking based on pocket-years and fibrinogen (r=0,341) total cholesterol (r=0.281) LDL levels (r=0.213) are found to be positively related albumin (r=-0.213) , GFR (r=-0.191) levels are found to be negatively related. Our results showed that in our meanly thirty four years aged young healty men cases cigarettes smoking disturbs lipid profile, effects nutritional parameters negatively, increases inflammatory markers and angiotension II levels and disturbs nephron functions with related to cigarette consumption daily based on pocket-years.
Abstract
It has been suggested that smoking increases the risk of atherosclerosis by disturbing the metabolism. Comorbidities like diabetes and hypertansion and other risk factors for atherosclerosis can’t be excluded in recent studies. Thus it makes difficult to define independent effects of smoking on metabolic structure-atherosclerosis. For this reason, we proposed to search about the effects of cigarette smoking on metabolic structure, renin-angiotensin system, inflammatory markers and nephron function in healthy men. In smoking cases waist circumference (p=0.017), BMI (p=0.035), fasting blood glucose (p=0.007), uric acid (p=0.013), albumin (p=0,003), creatinin (p=0,007) levels were found significantly low; GFR (p=0,013), leukocyte (p<0,001) and mean erythrocyte volume (p<0,001) levels were found significantly high. When we compared smokers less than ten pocket-years and more than ten pocket-years we found that in second group of cases albumin levels were low (p <0.05) and heart rate (p<0.005) , fibrinogen (p<0.005) and hs-CRP (p<0.005) levels were significantly high .In cases smoking more than twenty cigarettes daily comparing to cases smoking less than twenty cigarettes daily angiotensin II (p<0,005), leukocyte (p<0,05) levels were found significantly high. Cigarette smoking based on pocket-years and fibrinogen (r=0,341) total cholesterol (r=0.281) LDL levels (r=0.213) are found to be positively related albumin (r=-0.213) , GFR (r=-0.191) levels are found to be negatively related. Our results showed that in our meanly thirty four years aged young healty men cases cigarettes smoking disturbs lipid profile, effects nutritional parameters negatively, increases inflammatory markers and angiotension II levels and disturbs nephron functions with related to cigarette consumption daily based on pocket-years.
Açıklama
Tıpta Uzmanlık Tezi
Anahtar Kelimeler
Sigara, Dislipidemi, Ateroskleroz, Nikotin, Cigarette, Dyslipidemia, Atherosclerosis, Nicotine
