Protective effect of Lumbricus rubellus Hoffmeister extract in experimental renal ischemia/reperfusion injury in the nephrectomy rats

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dc.authoridÇivi Çetin, Kısmet/0000-0001-5420-9211
dc.authoridOzbayer, Cansu/0000-0002-1120-1874
dc.authorwosidÇivi Çetin, Kısmet/AAM-5670-2021
dc.authorwosidOzbayer, Cansu/F-6442-2015
dc.contributor.authorOz, Semih
dc.contributor.authorYildiz, Fatma
dc.contributor.authorKabay, Sahin
dc.contributor.authorSenturk, Hakan
dc.contributor.authorDonmez, Dilek Burukoglu
dc.contributor.authorOzbayer, Cansu
dc.contributor.authorUstuner, Mehmet Cengiz
dc.date.accessioned2024-06-12T10:52:09Z
dc.date.available2024-06-12T10:52:09Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAcute kidney injury (AKI), an immediate loss of renal function, leads to high mortality, and ischemia-reperfusion (I/R) injury is considered as one of the main causes of AKI. Inflammation and oxidative stress are known to play an important role in AKI. On the other hand, the earthworm extract, used in traditional medicine, is known to possess various biological and pharmacological activities viz. antiapoptotic, anticoagulative, fibrinolytic, anti-inflammatory, antioxidative stress, peripheral nerve regeneration, bone regeneration and wound healing. Hence, in this study, we investigated the protective effect of the earthworm Lumbricus rubellus Hoffmeister extract (LE) after nephrectomy, against oxidative stress occurring during renal ischemia/reperfusion (I/R) injury. A total of 10-12 weeks old Sprague Dawley male rats were divided into five groups (n=8). Group I (control), Group II (I/R), Group III (I/R + 10 mg/kg LE), Group IV (I/R + 20 mg/kg LE) and Group V (I/R + 40 mg/kg LE). All rats except in Gr. I were applied ischemia for 45 min and reperfusion for 24 h. At the end of the experiment, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) enzyme activities and malondialdehyde (MDA) levels were evaluated. In addition, kidney tissues were evaluated histologically. In results, the MDA and GPx level of the I/R group were found to be significantly higher than the control and LE groups. SOD activity of the control group did not differ when compared to LE groups and CAT levels were not significantly different between all groups. In addition, in Gr. III-V we observed nearly normal renal cortex and renal tubules. The present study, thus demonstrates that the extract of L. rubellus prevents renal I/R injury and induced biochemical and histological changes in the renal tissues in rats.en_US
dc.identifier.doi10.56042/ijeb.v61i12.1532
dc.identifier.endpage916en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue12en_US
dc.identifier.startpage911en_US
dc.identifier.urihttps://doi.org/10.56042/ijeb.v61i12.1532
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18594
dc.identifier.volume61en_US
dc.identifier.wosWOS:001112537100008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal Of Experimental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectEarthworm Extracten_US
dc.subjectKidneyen_US
dc.subjectReactive Oxygen Species (ROS)en_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectOxidative Stressen_US
dc.subjectWistar Ratsen_US
dc.subjectLumbrokinaseen_US
dc.subjectEarthwormen_US
dc.subjectInflammationen_US
dc.titleProtective effect of Lumbricus rubellus Hoffmeister extract in experimental renal ischemia/reperfusion injury in the nephrectomy ratsen_US
dc.typeArticleen_US

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