Investigation of the Relationship Between IL-18 (-607 C/A), IL-18 (-137 G/C), and MMP-2 (-1306 C/T) Gene Variations and Serum Copper and Zinc Levels in Patients Diagnosed with Chronic Renal Failure

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dc.authoridUstundag, Sedat/0000-0002-8502-9181
dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.contributor.authorAy, Arzu
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorUstundag, Sedat
dc.date.accessioned2024-06-12T10:56:31Z
dc.date.available2024-06-12T10:56:31Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the relationship between IL-18 (- 607 C/A), IL-18 (- 137 G/C), and MMP-2 (- 1306 C/T) gene variations and serum trace element levels in patients diagnosed with CRF. Genotype distributions of IL-18 (- 607 C/A, - 137 G/C) gene variations were determined by polymerase chain reaction (PCR) method. PCR-restriction fragment length polymorphism (RFLP) methods were used to determine the MMP-2 (- 1306 C/T) gene variation genotype distributions. Serum trace element levels were determined by atomic absorption spectrophotometer method. A significant difference was found between the CRF patient and healthy control groups in terms of genotype distributions of IL-18 (- 607 C/A) and MMP-2 (- 1306 C/T) gene variations (p < 0.05). The significant difference was found between the patient and control groups in terms of serum copper and zinc levels and copper/zinc ratio (p < 0.05). The significant difference was detected between patient and control groups in terms of copper and zinc levels and copper/zinc ratio according to IL-18 (- 607 C/A), IL-18 (- 137 G/C), and MMP-2 (- 1306 C/T) gene variations and genotype distributions (p < 0.05). In addition, significant difference was determined in terms of serum copper and zinc levels and copper/zinc ratio according to haplotypes of IL-18 (- 607 C/A), IL-18 (- 137 G/C), and MMP-2 (- 1306 C/T) gene variations between patient and control groups (p < 0.05). In conclusion, evaluation of IL-18 (- 607 C/A, - 137 G/C) and MMP-2 (- 1306 C/T) gene variations and serum trace element levels together is extremely important in terms of obtaining important biomarkers in CRF early diagnosis and progression.en_US
dc.identifier.doi10.1007/s12011-021-02828-6
dc.identifier.endpage2052en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue5en_US
dc.identifier.pmid34263421en_US
dc.identifier.scopus2-s2.0-85128652019en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2040en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02828-6
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19815
dc.identifier.volume200en_US
dc.identifier.wosWOS:000673391900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Renal Failureen_US
dc.subjectIL-18 (-607 Cen_US
dc.subjectA) Gene Variationen_US
dc.subjectIL-18 (-137 Gen_US
dc.subjectC) Gene Variationen_US
dc.subjectMMP-2 (-1306 Cen_US
dc.subjectT) Gene Variationen_US
dc.subjectTrace Elementsen_US
dc.subjectPCR-RFLPen_US
dc.subjectTrace-Elementsen_US
dc.subjectMatrix Metalloproteinase-2en_US
dc.subjectPolymorphismsen_US
dc.subjectInterleukin-18en_US
dc.subjectAssociationen_US
dc.subjectPromoteren_US
dc.subjectHemodialysisen_US
dc.subjectVariantsen_US
dc.subjectMetalsen_US
dc.titleInvestigation of the Relationship Between IL-18 (-607 C/A), IL-18 (-137 G/C), and MMP-2 (-1306 C/T) Gene Variations and Serum Copper and Zinc Levels in Patients Diagnosed with Chronic Renal Failureen_US
dc.typeArticleen_US

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