Synthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicin

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dc.authoridAltinkok, Cagatay/0000-0002-0262-4154
dc.authoridAcik, Gokhan/0000-0002-9427-0508
dc.authoridDag, Aydan/0000-0002-1552-8030
dc.authoridKarabulut, H.R. Ferhat/0000-0002-9501-6296
dc.authoridtasdelen, mehmet atilla/0000-0002-7012-7029
dc.authorwosidAltinkok, Cagatay/ABA-9208-2020
dc.authorwosidAcik, Gokhan/M-5880-2019
dc.authorwosidDag, Aydan/C-8435-2015
dc.authorwosidtasdelen, mehmet atilla/B-8338-2008
dc.contributor.authorAltinkok, Cagatay
dc.contributor.authorAcik, Gokhan
dc.contributor.authorKarabulut, Huseyin Riza Ferhat
dc.contributor.authorCiftci, Mustafa
dc.contributor.authorTasdelen, Mehmet Atilla
dc.contributor.authorDag, Aydan
dc.date.accessioned2024-06-12T10:51:28Z
dc.date.available2024-06-12T10:51:28Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn the present study, a polymeric micelle based on amphiphilic block copolymer, namely poly(methacrylated methyl lithocholate)-block-poly(oligoethylene glycol methacrylate) (PMML-b-POEGMA) bearing bile acid moiety is prepared via sequential photo-initiated free radical polymerizations, and its drug carrying capacity is investigated using doxorubicin hydrochloride (DOX) as a model drug. For this purpose, two-step procedure is applied in the presence of phenylbis (2,4,6-trimethylbenzoyl)phosphine oxide (BAPO) as bifunctional photo initiator. Based on spectroscopic and chromatographic analyses, the desired amphiphilic block copolymer (PMML-b-POEGMA) is successfully synthesized by wavelength-selective free radical photopolymerization under mild conditions. Finally, the DOX drug is loaded into the PMML-b-POEGMA micelles and then drug release behavior is investigated at two different pH (5.5 and 7.4) values. It is concluded from the results that PMML-b-POEGMA micelles may be used as an efficient nanocarrier to deliver conventional anti-cancer drugs for combination chemotherapy.en_US
dc.description.sponsorshipTrakya University [2018/278]en_US
dc.description.sponsorshipTrakya University, Grant/Award Number: 2018/278en_US
dc.identifier.doi10.1002/pat.5478
dc.identifier.endpage4868en_US
dc.identifier.issn1042-7147
dc.identifier.issn1099-1581
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85113231474en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4860en_US
dc.identifier.urihttps://doi.org/10.1002/pat.5478
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18379
dc.identifier.volume32en_US
dc.identifier.wosWOS:000687189400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPolymers For Advanced Technologiesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmphiphilicen_US
dc.subjectDrug Releaseen_US
dc.subjectLithocholic Aciden_US
dc.subjectPhotopolymerizationen_US
dc.subjectCholic-Aciden_US
dc.subjectPhotoinitiated Polymerizationen_US
dc.subjectPoly(Ethylene Glycol)en_US
dc.subjectCopolymersen_US
dc.subjectAggregationen_US
dc.subjectTransporten_US
dc.subjectReleaseen_US
dc.subjectBindingen_US
dc.subjectPhen_US
dc.titleSynthesis and characterization of bile acid-based polymeric micelle as a drug carrier for doxorubicinen_US
dc.typeArticleen_US

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