The Effect of TGFB1 and CD14 Gene Polymorphisms on the Clinical Findings of Cystic Fibrosis in Turkish Patients

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dc.authoridGürkan, Hakan/0000-0002-8967-6124;
dc.authorwosidTamay, Zeynep/AAE-5668-2020
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.authorwosidakgul, sebahat usta/AAE-7495-2020
dc.authorwosidcinar, cigdem kekik/AAD-4224-2020
dc.authorwosidTemurhan, Sonay/AAD-4168-2020
dc.contributor.authorTemurhan, Sonay
dc.contributor.authorTamay, Zeynep
dc.contributor.authorGurkan, Hakan
dc.contributor.authorAkgul, Sebahat
dc.contributor.authorOzceker, Deniz
dc.contributor.authorKekik, Cigdem
dc.contributor.authorCagatay, Penbe
dc.date.accessioned2024-06-12T10:55:58Z
dc.date.available2024-06-12T10:55:58Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSignificant effects of several modifying genes on the clinical features of cystic fibrosis (CF) have been reported. In the present study, the researchers investigated the effects of transforming growth factor beta 1 (TGFB1) and cluster of differentiation 14 (CD14) polymorphisms on the clinical status of patients with CF. The present study included sixty-five patients with CF and eighty five healthy controls with no pulmonary disease. Single-nucleotide polymorphisms in the TGFB1 gene (rs1800469, rs1800470, rs8179181) were studied using DNA sequence analyses; the CD14 gene polymorphism rs2569190 was evaluated using restriction fragment length polymorphism analysis. The frequency of rs1800469 (TT genotype) was significantly higher in the healthy controls than in the patients with CF. Thus, the TT genotype may be protective against CF. Although rs8179181 (CT genotype) may have an overall negative effect, this genotype may have a favourable effect on growth parameters. However, these results should be confirmed in larger studies.en_US
dc.description.sponsorshipIstanbul University Scientific Research Projects Unit [9523]en_US
dc.description.sponsorshipThis study was supported by the Istanbul University Scientific Research Projects Unit (Project no. 9523).en_US
dc.identifier.doi10.1080/09723757.2016.11886276
dc.identifier.endpage47en_US
dc.identifier.issn0972-3757
dc.identifier.issue1-2en_US
dc.identifier.scopus2-s2.0-84978945581en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage40en_US
dc.identifier.urihttps://doi.org/10.1080/09723757.2016.11886276
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19621
dc.identifier.volume16en_US
dc.identifier.wosWOS:000381656300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKamla-Raj Enterprisesen_US
dc.relation.ispartofInternational Journal Of Human Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCD14en_US
dc.subjectRs1800469en_US
dc.subjectRs1800470en_US
dc.subjectRs2569190en_US
dc.subjectRs8179181en_US
dc.subjectTransforming Growth Factor Beta 1 (TGFB1)en_US
dc.subjectLung-Disease Severityen_US
dc.subjectLiver-Diseaseen_US
dc.subjectNutritional-Statusen_US
dc.subjectModifier Genesen_US
dc.subjectGenotypeen_US
dc.subjectAssociationen_US
dc.subjectChildrenen_US
dc.subjectDisordersen_US
dc.subjectMutationsen_US
dc.subjectPhenotypeen_US
dc.titleThe Effect of TGFB1 and CD14 Gene Polymorphisms on the Clinical Findings of Cystic Fibrosis in Turkish Patientsen_US
dc.typeArticleen_US

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