Effect of Leptin and Apelin Preconditioning on Hepatic Ischemia Reperfusion Injury in Rats

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dc.authoridsagiroglu, gonul/0000-0002-1189-4973
dc.authorwosidsagiroglu, gönül/AAB-4472-2021
dc.authorwosidSagiroglu, Gonul/ABH-1345-2021
dc.authorwosidOguz, Serhat/HKE-2793-2023
dc.contributor.authorSagiroglu, Tamer
dc.contributor.authorAksoy, Mustafa Burak
dc.contributor.authorSagiroglu, Gonul
dc.contributor.authorTozkir, Hilmi
dc.contributor.authorOguz, Serhat
dc.contributor.authorYalta, Tulin
dc.contributor.authorYagci, Mehmet A.
dc.date.accessioned2024-06-12T11:07:06Z
dc.date.available2024-06-12T11:07:06Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractLeptin and apelin are important adipocytokines involved in a variety of endocrine and paracrine functions. The aim of this study was to evaluate the effect of exogenous leptin and apelin preconditioning on hepatic ischemia reperfusion (I/R) injury in rats. Forty mice were assigned to four groups (n = 10): sham-operated control (sham), I/R injury, I/R + leptin (I/R + L), and I/R + apelin (I/R + A). Leptin 100 mu g/kg/day and apelin 2 mu g/kg/day were delivered intraperitoneally starting 3 days prior to surgical procedure in I/R + L and I/R + A groups, respectively. All I/R groups underwent 45 min of warm ischemia, followed by 30 min of reperfusion. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), liver malondialdehyde (MDA) and glutathione (GSH), and liver histopathology were compared between groups. MDA was elevated in I/R, but stayed similar in I/R + L and I/R + A compared to sham. I/R + A had significantly lower MDA compared to I/R. GSH levels did not differ significantly between the groups. ALT and AST were elevated in all I/R groups, but significant reduction was observed in I/R + L and I/R + A compared to I/R. Liver histopathology was mostly mild in I/R + L and I/R + A, in contrast to severe injury observed in the I/R group. Leptin and apelin preconditioning significantly reduced hepatic I/R injury in rats.en_US
dc.identifier.doi10.1007/s12262-012-0676-4
dc.identifier.endpage116en_US
dc.identifier.issn0972-2068
dc.identifier.issn0973-9793
dc.identifier.issue2en_US
dc.identifier.pmid24891774en_US
dc.identifier.scopus2-s2.0-84901832522en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage111en_US
dc.identifier.urihttps://doi.org/10.1007/s12262-012-0676-4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21894
dc.identifier.volume76en_US
dc.identifier.wosWOS:000336981800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia Reperfusion Injuryen_US
dc.subjectLiveren_US
dc.subjectLeptinen_US
dc.subjectApelinen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectNitric-Oxideen_US
dc.subjectLiveren_US
dc.subjectProtectsen_US
dc.subjectHearten_US
dc.subjectHormoneen_US
dc.subjectLiganden_US
dc.subjectApjen_US
dc.titleEffect of Leptin and Apelin Preconditioning on Hepatic Ischemia Reperfusion Injury in Ratsen_US
dc.typeArticleen_US

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