Subcutaneous Adipose Tissue Type II Deiodinase Gene Expression Reduced in Obese Individuals with Metabolic Syndrome

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dc.authoridBalci, Sibel Oguzkan/0000-0003-0537-3028
dc.authoridBorazan, Ersin/0000-0002-3620-0093
dc.authoridAkarsu, Ersin/0000-0003-2786-6616
dc.authoridOguzkan Balci, Sibel/0000-0003-0537-3028;
dc.authorwosidBalci, Sibel Oguzkan/ABF-1043-2020
dc.authorwosid, mehmet/AAG-6430-2020
dc.authorwosidBorazan, Ersin/AAH-1430-2020
dc.authorwosidAkarsu, Ersin/AAH-4325-2020
dc.authorwosidKAPLAN, MEHMET/AAA-9808-2020
dc.authorwosidOguzkan Balci, Sibel/A-1768-2016
dc.authorwosidKorkmaz, Selma/JRX-3713-2023
dc.contributor.authorAkarsu, E.
dc.contributor.authorKorkmaz, H.
dc.contributor.authorBalci, S. Oguzkan
dc.contributor.authorBorazan, E.
dc.contributor.authorKorkmaz, S.
dc.contributor.authorTarakcioglu, M.
dc.date.accessioned2024-06-12T10:59:24Z
dc.date.available2024-06-12T10:59:24Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe present study aimed to evaluate the role of subcutaneous adipose tissue (SAT) type II deiodinase enzyme gene (DIO2) expression in developing metabolic syndrome (MetS). A total of 51 obese patients with MetS and without MetS and 13 healthy subjects enrolled in the study. Body mass index (BMI), waist circumference (WC), waist-to-hip circumference ratio (WHR), hip circumference, and systolic (SBP) and diastolic blood pressures (DBP) of all subjects were recorded. Fasting plasma glucose (FPG), fasting plasma insulin, high density lipoprotein- cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), total cholesterol (TC) and triglyceride (TG) of all subjects were analyzed. Expression of the DIO2 gene in adipose tissue was determined by reverse transcription polymerase chain reaction (qRT-PCR). BMI, WC and WHR were not significantly difference between obese with and without MetS. SBP, DBP, FPG and TG were significantly higher in obese with MetS group than obese without MetS group. While the free triiodothyronine (T3) level was in the normal range in all group, it was significantly lower in the obese with MetS than both obese without MetS and control group. DIO2 expression was significantly lower in the obese with MetS group compared to the control. In correlation analysis, DIO2 expression was negatively correlated with DBP, TG and homeostasis model assessment of insulin resistance (HOMA-IR) levels and positively correlated with free T3. In conclusion, the reduction of SAT DIO2 expression is negatively correlated with DBP and TG levels that are associated with the MetS. This might have an effect on developing MetS. We believe that DIO2 gene may be an important molecular target for future studies in developing targeted treatment options for obese people with MetS.en_US
dc.description.sponsorshipGaziantep University Medical Faculty Scientific Research Support Funden_US
dc.description.sponsorshipThis study has receieved financial support from Gaziantep University Medical Faculty Scientific Research Support Fund.en_US
dc.identifier.doi10.1055/s-0035-1564129
dc.identifier.endpage15en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue1en_US
dc.identifier.pmid26588490en_US
dc.identifier.scopus2-s2.0-84955365297en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.1055/s-0035-1564129
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20432
dc.identifier.volume124en_US
dc.identifier.wosWOS:000368943100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbhen_US
dc.relation.ispartofExperimental And Clinical Endocrinology & Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDIO2en_US
dc.subjectMetabolic Syndromeen_US
dc.subjectObesityen_US
dc.subjectSubcutaneous Adipose Tissueen_US
dc.subjectInsulin-Resistanceen_US
dc.subjectThr92ala Polymorphismen_US
dc.subjectThyroid-Functionen_US
dc.subjectAssociationen_US
dc.subjectHypothyroidismen_US
dc.subjectHormonesen_US
dc.titleSubcutaneous Adipose Tissue Type II Deiodinase Gene Expression Reduced in Obese Individuals with Metabolic Syndromeen_US
dc.typeArticleen_US

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