Protective effect of Urtica dioica L. on renal ischemia/reperfusion injury in rat

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dc.authorwosidOguz, Serhat/HKE-2793-2023
dc.contributor.authorSayhan, Mustafa Burak
dc.contributor.authorKanter, Mehmet
dc.contributor.authorOguz, Serhat
dc.contributor.authorErboga, Mustafa
dc.date.accessioned2024-06-12T11:13:36Z
dc.date.available2024-06-12T11:13:36Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractRenal ischemia-reperfusion (I/R) injury may occur after renal transplantation, thoracoabdominal aortic surgery, and renal artery interventions. This study was designed to investigate the effect of Urtica dioica L. (UD), in I/R induced renal injury. A total of 32 male Sprague-Dawley rats were divided into four groups: control, UD alone, I/R and I/R + UD; each group contain 8 animals. A rat model of renal I/R injury was induced by 45-min occlusion of the bilateral renal pedicles and 24-h reperfusion. In the UD group, 3 days before I/R, UD (2 ml/kg/day intraperitoneal) was administered by gastric gavage. All animals were sacrificed at the end of reperfusion and kidney tissues samples were obtained for histopathological investigation in all groups. To date, no more histopathological changes on intestinal I/R injury in rats by UD treatment have been reported. Renal I/R caused severe histopathological injury including tubular damage, atrophy dilatation, loss of brush border and hydropic epithelial cell degenerations, renal corpuscle atrophy, glomerular shrinkage, markedly focal mononuclear cell infiltrations in the kidney. UD treatment significantly attenuated the severity of intestinal I/R injury and significantly lowered tubulointerstitial damage score than the I/R group. The number of PCNA and TUNEL positive cells in the control and UD alone groups was negligible. When kidney sections were PCNA and TUNEL stained, there was a clear increase in the number of positive cells in the I/R group rats in the renal cortical tissues. However, there is a significant reduction in the activity of PCNA and TUNEL in kidney tissue of renal injury induced by renal I/R with UD therapy. Our results suggest that administration of UD attenuates renal I/R injury. These results suggest that UD treatment has a protective effect against renal damage induced by renal I/R. This protective effect is possibly due to its ability to inhibit I/R induced renal damage, apoptosis and cell proliferation.en_US
dc.identifier.doi10.1007/s10735-012-9436-9
dc.identifier.endpage698en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue6en_US
dc.identifier.pmid22760215en_US
dc.identifier.scopus2-s2.0-84877113167en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage691en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-012-9436-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23591
dc.identifier.volume43en_US
dc.identifier.wosWOS:000312129900009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenal Ischemia/Reperfusionen_US
dc.subjectRenal Injuryen_US
dc.subjectProliferation And Apoptosisen_US
dc.subjectUrtica Dioicaen_US
dc.subjectRaten_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectNigella-Sativaen_US
dc.subjectApoptosisen_US
dc.subjectAntioxidanten_US
dc.subjectFailureen_US
dc.subjectRegenerationen_US
dc.subjectInhibitionen_US
dc.subjectQuercetinen_US
dc.subjectKidneyen_US
dc.titleProtective effect of Urtica dioica L. on renal ischemia/reperfusion injury in raten_US
dc.typeArticleen_US

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