Values and correlations between C-reactive protein and apolipoprotein B after treatment with methotrexate at patients with rheumatoid arthritis
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Open Access Macedonian Journal of Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
BACKGROUND: Patients with rheumatoid arthritis (RA) are at increased risk of cardiovascular disease (CVD). Lipid changes related to inflammation have been described in RA. Methotrexate (MTX) treatment is effective in controlling inflammation and decreasing the CRP (C-reactive protein) values. AIM: To examine the disease activity, CRP and Apo B values in the detection of new patients with active and untreated RA, and impact of MTX therapy on their levels after 6 months and one year of treatment, and the correlation between their values in this period. METHODS: 80 patients with active and newly discovered RA patients who meet the American Rheumatology Association (ARA) 1987 revised criteria were treated with disease-modifying anti-inflammatory drugs (DMARDs) according to the protocol for treatment. RESULTS: After a year of therapy RA patients achieved significant decrease in the DAS28 (disease activity score) (p < 0.01 and p < 0.001), and CRP values (p < 0.001). Levels of Apo B values at the 12 months were nonsignificantly higher compared to the results obtained at the beginning of the study (p < 0.001). After 6 and 12 months there was a weak nonsignificant negative correlation about the values of CRP and Apo B at baseline and after 12 months (r = –0.15 and r =-0.12 p > 0.05). CONCLUSION: Use of MTX therapy at RA patients had a reduced effect on disease activity and inflammation, but the nonsignificance effect on the values of Apo B lipoproteins. © 2019 Hysni Ismaili, Levent Ismaili, Meral Rexhepi.
Açıklama
Anahtar Kelimeler
Apolipoprotein B (Apo B); C-Reactive Protein (Crp); Methotrexate (Mtx); Rheumatoid Arthritis (Ra), Apolipoprotein B; C Reactive Protein; Disease Modifying Antirheumatic Drug; Methotrexate; Rheumatoid Factor; Adult; Article; Body Mass; Cardiovascular Disease; Cardiovascular Risk; Das28; Disease Activity; Disease Activity Score; Disease Duration; Erythrocyte Sedimentation Rate; Female; Follow Up; Human; Inflammation; Joint Swelling; Major Clinical Study; Male; Middle Aged; Morning Stiffness; Questionnaire; Rheumatoid Arthritis; Visual Analog Scale
Kaynak
Open Access Macedonian Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
7
Sayı
8
