Wound-Healing Species of Euphorbia L.

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dc.authoridISCAN, Gülçin SALTAN/0000-0001-6633-0713
dc.authoridOZBILGIN, Serkan/0000-0002-3945-6756
dc.authoridSUNTAR, IPEK/0000-0003-4201-1325
dc.authorwosidAkkol, Esra/ABI-4678-2020
dc.authorwosidSüntar, İpek/AHE-1026-2022
dc.authorwosidISCAN, Gülçin SALTAN/AAG-8646-2020
dc.contributor.authorOzbilgin, Serkan
dc.contributor.authorAkkol, Esra Kupeli
dc.contributor.authorSuntar, Ipek
dc.contributor.authorTekin, Mehmet
dc.contributor.authorIscan, Gulcin Saltan
dc.date.accessioned2024-06-12T11:01:32Z
dc.date.available2024-06-12T11:01:32Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSome species of Euphorbia have been used as medicinal plants to treat wounds, and skin diseases, around the world. The solvents n-hexane, ethyl acetate, and methanol were used successively to prepare extracts of the aerial parts of E. characias subsp. wulfenii, E. helioscopia, E. macroclada, E. seguieriana subsp. seguieriana, and E. virgata. Linear incision, circular excision wound models and the hydroxyproline assay method were used to assess the wound-healing activity. The inhibition of the increase in capillary permeability induced by acetic acid was used to assay the anti-inflammatory activity. The methanol extract of the aerial parts of E. characias subsp. wulfenii showed statistically significant wound-healing activity with 43.03% tensile strength for the linear incision wound model and a 65.24% reduction in the area of the wound by day 10 for the circular excision model. The tissue treated with this extract was found to contain 35.47 mu g/mg of hydroxyproline. The methanol extract of E. characias subsp. wulfenii inhibited inflammation induced by acetic acid with a value of 34.74%. The results showed that the aerial parts of E. characias subsp. wulfenii possess wound-healing and anti-inflammatory activities on different models.en_US
dc.description.sponsorshipAnkara University Scientific Research Projects Coordination Unit [13L3336004]en_US
dc.description.sponsorshipThis work was financially supported by the Ankara University Scientific Research Projects Coordination Unit [Project Number: 13L3336004].en_US
dc.identifier.doi10.25135/rnp.81.18.03.255
dc.identifier.endpage113en_US
dc.identifier.issn1307-6167
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85058037125en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage104en_US
dc.identifier.trdizinid345376en_US
dc.identifier.urihttps://doi.org/10.25135/rnp.81.18.03.255
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/345376
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20932
dc.identifier.volume13en_US
dc.identifier.wosWOS:000455645400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAcg Publicationsen_US
dc.relation.ispartofRecords Of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEuphorbiaen_US
dc.subjectAnti-Inflammatoryen_US
dc.subjectExcisionen_US
dc.subjectIncisionen_US
dc.subjectWound-Healingen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectAntiinflammatory Activityen_US
dc.subjectAntibacterial Activityen_US
dc.subjectTraditional Medicineen_US
dc.subjectAntioxidant Activityen_US
dc.subjectFolk Medicineen_US
dc.subjectExtracten_US
dc.subjectHirtaen_US
dc.subjectMetabolitesen_US
dc.subjectBioassayen_US
dc.titleWound-Healing Species of Euphorbia L.en_US
dc.typeArticleen_US

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