Synthesis and molecular docking studies of some novel antimicrobial benzamides

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dc.authoridYildiz, Ilkay/0000-0001-9526-0232
dc.authoridYALÇIN, Gözde/0000-0002-9689-2239
dc.authoridAcar, Cemre/0000-0001-8965-3267
dc.authorwosidYildiz, Ilkay/A-1851-2016
dc.authorwosidErtan-Bolelli, Tugba/G-2237-2014
dc.authorwosidOkten, Suzan/HGV-1334-2022
dc.authorwosidÖkten, Suzan/HJH-6316-2023
dc.authorwosidONURDAG, Fatma KAYNAK/T-2518-2017
dc.authorwosidYALÇIN, Gözde/B-8759-2017
dc.contributor.authorAcar, Cemre
dc.contributor.authorYalcin, Gozde
dc.contributor.authorErtan-Bolelli, Tugba
dc.contributor.authorOnurdag, Fatma Kaynak
dc.contributor.authorOkten, Suzan
dc.contributor.authorSener, Funda
dc.contributor.authorYildiz, Ilkay
dc.date.accessioned2024-06-12T10:54:23Z
dc.date.available2024-06-12T10:54:23Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCommon use of classical antibiotics has caused to the growing emergence of many resistant strains of pathogenic bacteria. Therefore, we aimed to synthesize a number of N-(2-hydroxy-(4 or 5)-nitrophenyl)benzamide derivatives as a new class of antimicrobial compounds. Moreover, our second goal is to predict the interaction between active structures and enzymes (DNA-gyrase and FtsA) in the binding mode. In this study, thirteen N-(2-hydroxy-(4 or 5-nitrophenyl)-substituted-benzamides were synthesized and determined for their antimicrobial activity using the microdilution method. According to this work, none of the compounds showed any activity against Candida albicans and its clinical isolate. Some of the benzamides (4N1, 5N1, 5N2) displayed very significant activity against Staphylococcus aureus and MSSA with < 4 mu g/ml MIC value, even they were found to be more potent than ceftazidime. 4N1 was also found to be more effective than gentamicin against Enterococcus faecalis clinical isolate. Molecular docking studies revealed that 4N1, 5N1, and 5N2 showed a good interactions with DNA-gyrase. Moreover, 5N1 has interacted with FtsA enzyme in the binding mode, as well. Only compound 5N4 displayed very good activity against Escherichia coli ATCC 25922. These findings showed us that 4N1, 5N1, 5N2, and 5N4 could be lead compounds to discover new antibacterial candidates against multidrug-resistant strains.en_US
dc.identifier.doi10.1016/j.bioorg.2019.103368
dc.identifier.issn0045-2068
dc.identifier.issn1090-2120
dc.identifier.pmid31699395en_US
dc.identifier.scopus2-s2.0-85074896451en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2019.103368
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19033
dc.identifier.volume94en_US
dc.identifier.wosWOS:000505596300026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Inc Elsevier Scienceen_US
dc.relation.ispartofBioorganic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzamideen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectMolecular Dockingen_US
dc.subjectDNA-Gyraseen_US
dc.subjectFtsaen_US
dc.subjectMicrobiological Activityen_US
dc.subjectPossible Metabolitesen_US
dc.subjectDna Gyraseen_US
dc.subjectPhenylacetamidesen_US
dc.subjectInhibitorsen_US
dc.subjectDerivativesen_US
dc.subjectResistanceen_US
dc.subjectDesignen_US
dc.subjectAmidesen_US
dc.subjectBugsen_US
dc.titleSynthesis and molecular docking studies of some novel antimicrobial benzamidesen_US
dc.typeArticleen_US

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