Arginase and Ornithine in Human Benign and Malignant Skin Tumors

Basit Öğe Kaydı
dc.contributor.authorGokmen, Selma Suer
dc.contributor.authorKazezoglu, Cemal
dc.contributor.authorAygit, A. Cemal
dc.contributor.authorYildiz, Reyhan
dc.contributor.authorCakir, Beyhan
dc.contributor.authorTure, Mevlut
dc.contributor.authorGulen, Sendogan
dc.date.accessioned2024-06-12T10:52:29Z
dc.date.available2024-06-12T10:52:29Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Arginase activity and ornithine concentration have been shown to be elevated in experimentally-induced benign tumors in mice. The aim of the study is to investigate arginase activity and ornithine concentration in human benign and malignant skin tumors and to evaluate their role for prognosis of skin tumors. Patients and Methods: We have investigated arginase activity and ornithine concentration in supernatant of homogenates of benign tumors (nevus) of the skin from 13 patients and of malignant tumors (squamous cell or basal cell carcinomas) from 29 patients. Total arginase activity, ornithine and total protein concentration in supernatant were determined by the methods of Geyer, Chinard and Lowry, respectively. Results: Arginase activity (p=0.006) and ornithine concentration (p=0.007) in nevus were significantly higher than in adjacent normal tissue. There was no significant difference between their levels in basal cell carcinoma and in nevus (p>0.05). There was no significant difference between ornithine concentration in squamous cell carcinoma and in nevus (p>0.05). However, arginase activity in this carcinoma was significantly higher than in nevus (p=0.018). Conclusion: The significant difference between tissue arginase activities in squamous cell carcinoma and in nevus indicates that determination of arginase activity could be useful for prognosis of skin tumors.en_US
dc.identifier.endpage324en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-78651410987en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage319en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18722
dc.identifier.volume35en_US
dc.identifier.wosWOS:000285648800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArginaseen_US
dc.subjectOrnithineen_US
dc.subjectNevusen_US
dc.subjectSquamous Cell Carcinomaen_US
dc.subjectBasal Cell Carcinomaen_US
dc.subjectNitric-Oxideen_US
dc.subjectProstatic-Carcinomaen_US
dc.subjectCanceren_US
dc.subjectHyperplasiaen_US
dc.subjectExpressionen_US
dc.subjectTissueen_US
dc.subjectDecarboxylaseen_US
dc.subjectMetabolismen_US
dc.subjectPolyaminesen_US
dc.subjectInductionen_US
dc.titleArginase and Ornithine in Human Benign and Malignant Skin Tumorsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu