Molecular docking studies on some benzamide derivatives as topoisomerase inhibitors

Simple item page
dc.authorscopusid55737196700
dc.authorscopusid55963577900
dc.authorscopusid6603772410
dc.contributor.authorYilmaz S.
dc.contributor.authorAtaei S.
dc.contributor.authorYildiz I.
dc.date.accessioned2024-06-12T10:25:59Z
dc.date.available2024-06-12T10:25:59Z
dc.date.issued2020
dc.description.abstractObjective: In order to examine the interactions of some benzamide derivatives, which are thought to exhibit anti-cancer activity, with human Topo I and II? enzymes at the molecular level, docking studies were carried out on these enzymes. Material and Method: In conducting the docking studies, the protein was selected from the protein data bank for Topo I (1K4T) and for Topo II? (5GWK). Doking was performed with the CDocker method using the Discovery studio 3.5 program, and the binding energies of benzamide derivatives to enzymes were calculated and their molecular interactions were revealed. Result and Discussion: As a result of the docking process on Topo I and II?, it was found that benzamide derivative compounds have higher affinity for Topo II? enzyme. For Topo I compounds 4N6, 5N5; for Topo IIa compounds 5N3, 5N7 have been identified as promising compounds in terms of anticancer activity. © 2020 University of Ankara. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.789537
dc.identifier.endpage480en_US
dc.identifier.issn2564-6524
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85092615464en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage470en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.789537
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16611
dc.identifier.volume44en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnticancer; Benzamide; Docking; Topoisomerase I; Topoisomerase Iiaen_US
dc.subjectAmino Acid; Antineoplastic Agent; Benzamide Derivative; Camptothecin; Dna Topoisomerase Inhibitor; Etoposide; Hydroxyl Group; Antineoplastic Activity; Article; Controlled Study; Drug Protein Binding; Drug Synthesis; Hydrogen Bond; Molecular Docking; Molecular Interaction; Protein Data Banken_US
dc.titleMolecular docking studies on some benzamide derivatives as topoisomerase inhibitorsen_US
dc.title.alternativeTopoizomeraz inhibitörleri olarak bazi benzamid türevleri üzerinde moleküler doking c?lismalarien_US
dc.typeArticleen_US

Files

Collections

Scopus İndeksli Yayınlar Koleksiyonu

We collect and process your personal information for the following purposes: Authentication, Preferences, Acknowledgement and Statistics.
To learn more, please read our privacy policy.

Customize