Cytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Lines

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dc.authorwosidgüneş, fatma/ABI-3529-2020
dc.contributor.authorUgur, Deniz
dc.contributor.authorGunes, Hatice
dc.contributor.authorGunes, Fatma
dc.contributor.authorMammadov, Ramazan
dc.date.accessioned2024-06-12T10:59:08Z
dc.date.available2024-06-12T10:59:08Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: In recent years, the use of plants for the prevention and treatment of cancer is gaining more attention due to their diverse range of phytochemical constituents and fewer adverse effects. In this study, four medicinal plant species from the Kars province of Turkey were investigated for their cytotoxic potential against six different cancer cell lines and one normal cell line. Materials and Methods: MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide] assay was performed to assess cytotoxic activity and apoptotic effect was determined using flow cytometry and caspase-3 analyses. Results: Significant cytotoxicity (>= 70%) was observed with the leaf extract of Artemisia absinthium on A-549, CCC-221, K-562, MCF-7, PC-3 cells,whereas seed extracts caused significant cytotoxicity (>= 70%) on CCC-221, K-562, MCF-7, PC-3 cells. Selective cytotoxicity was obtained with leaf extract on A-549 and K-562 cells; and with seed extract on K-562, MCF-7 and PC-3 cells compared with normal Beas-2B cells. The levels of cytotoxicity for both extracts were time-and dose-dependent at lower concentrations. Moreover, selective cytotoxicity (78%) was detected on A-549 cells with the seed extract of Plantago major. Cytotoxicity of extracts from Hyoscyamus niger and Amaranthus retrosa ranged between 10% and 30%. Conclusion: A. absinthium extracts and P. major seed extract have potential for development as therapeutic agents for cytotoxicity on certain cancer cells following further investigation.en_US
dc.description.sponsorshipScientific Research Projects (BAP) of Mugla Sitki Kocman University [13/82]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects (BAP) of Mugla Sitki Kocman University under project number 13/82.en_US
dc.identifier.doi10.4274/tjps.80299
dc.identifier.endpage230en_US
dc.identifier.issn1304-530X
dc.identifier.issue3en_US
dc.identifier.pmid32454617en_US
dc.identifier.scopus2-s2.0-85034961083en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage222en_US
dc.identifier.urihttps://doi.org/10.4274/tjps.80299
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20328
dc.identifier.volume14en_US
dc.identifier.wosWOS:000417379400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Pharmacists Assocen_US
dc.relation.ispartofTurkish Journal Of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytotoxicityen_US
dc.subjectCancer Cellsen_US
dc.subjectMedicinal Plantsen_US
dc.subjectApoptosisen_US
dc.subjectArtemisia Absinthiumen_US
dc.subjectArtemisiaen_US
dc.subjectApoptosisen_US
dc.titleCytotoxic Activities of Certain Medicinal Plants on Different Cancer Cell Linesen_US
dc.typeArticleen_US

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