A different approach to telomere analysis with ddPRINS in chronic lymphocytic leukemia

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dc.authoridSERAKINCI, Nedime/0000-0002-1884-0839
dc.authorwosidOzturk, Sukru/AAC-5001-2020
dc.contributor.authorPalanduz, S
dc.contributor.authorSerakinci, N
dc.contributor.authorCefle, K
dc.contributor.authorAktan, M
dc.contributor.authorTutkan, G
dc.contributor.authorOzturk, S
dc.contributor.authorBozkurt, G
dc.date.accessioned2024-06-12T10:56:30Z
dc.date.available2024-06-12T10:56:30Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTelomeric sequences, located at the very end of the chromosomes, compensate for the chromosomal shortening as it happens after each round of cell division. Telomeric sequences influence the progress of cellular senescence and cancer progression. It has been reported that telomeres are shortened in acute leukemias where the cell turnover is high. B-cell chronic lymphocytic leukemia (CLL) is a particularly interesting haematological malignancy in regard to telomere dynamics because most of the malignant cells in CLL are mitotically inactive. In this study, we analysed the telomere length in patients with B-cell CLL in a comparison with the control group by using ddPRINS technique. Twenty patients with CLL and four healthy donors as a control group were included. We found short telomeres and no detectable telomeric repeats at the sites of chromosome fusion. We hypothesise that the telomeric erosion in CLL may reflect the dominance of malignant cells with an abnormally long life span. These cells may have encountered many antigenic stimulants in the past and hence underwent multiple clonal expansions. Our findings imply that shortened telomeres in CLL may be reflecting the history of the disease and serve as an independent prognostic factor. (c) 2004 Published by Elsevier SAS.en_US
dc.identifier.doi10.1016/j.ejmg.2005.01.023
dc.identifier.endpage69en_US
dc.identifier.issn1769-7212
dc.identifier.issue1en_US
dc.identifier.pmid16473311en_US
dc.identifier.scopus2-s2.0-32244435282en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage63en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejmg.2005.01.023
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19803
dc.identifier.volume49en_US
dc.identifier.wosWOS:000236088100008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Medical Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Lymphocytic Leukemiaen_US
dc.subjectTelomereen_US
dc.subjectMalignant Hematopoietic-Cellsen_US
dc.subjectIn-Situen_US
dc.subjectDnaen_US
dc.subjectLengthen_US
dc.subjectHypothesisen_US
dc.subjectVivoen_US
dc.titleA different approach to telomere analysis with ddPRINS in chronic lymphocytic leukemiaen_US
dc.typeArticleen_US

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