The -31 G/C promoter gene polymorphism of survivin in Turkish patients with colorectal cancer
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sri Lanka Medical Assoc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction Survivin (also known as birc5) is the first protein discovered among the apoptosis-regulating gene family referred to as inhibitor of apoptosis proteins (IAPs). It is expressed and controlled during cellular differentiation and development in human beings. Survivin expression has been shown in a number of cancers and has been associated with cancer development. Objective In our study, we compared normal and tumoural tissue samples, which were obtained from 100 patients diagnosed with colorectal cancer, at Department of Pathology, Istanbul University. Methods The present study employed PCR-RFLP to identify the -31 G/C polymorphism in the promoter region of the survivin gene. Distribution of the survivin polymorphism was compared between control and tumoural tissue samples using the chi-square test. Results Comparison of all samples revealed that there was significant difference in distribution of survivin promoter -31G/C between tumour and normal tissue of the patient group (p<0.05). When genotypes were compared according to gender, there was no statistically significant difference in the distribution of survivin promoter -31G/C in females p=0.420 or males p=0.309. Conclusion A significant difference was seen in distribution of C allele in tumour tissue compared to normal tissue.
Açıklama
Anahtar Kelimeler
Antiapoptosis Gene, Risk, Expression
Kaynak
Ceylon Medical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
63
Sayı
3
