In vitro effects of amiodarone on coronary artery bypass grafts

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dc.authoridKalender, Mehmet/0000-0002-8984-4028
dc.authoridECEVIT, ATA NIYAZI/0000-0002-8820-9305
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidKalender, Mehmet/D-1202-2019
dc.authorwosidEcevit, Ata Niyazi/Z-1436-2019
dc.authorwosidECEVIT, ATA NIYAZI/ACQ-5909-2022
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorKaraca, Okay Guven
dc.contributor.authorEge, Turan
dc.contributor.authorCanbaz, Suat
dc.contributor.authorGur, Ozcan
dc.contributor.authorKaradag, Cetin Hakan
dc.contributor.authorEcevit, Ata Niyazi
dc.contributor.authorKalender, Mehmet
dc.date.accessioned2024-06-12T10:51:26Z
dc.date.available2024-06-12T10:51:26Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: This study aims to investigate the effects of amiodarone on the most commonly used grafts, internal thoracic artery (ITA), saphenous vein (SV), and radial artery (RA) in organ bath. Methods: Twenty patients (16 males, 4 females; mean ages 58.4 +/- 9.9 years; range 38 to 80 years) who underwent isolated coronary artery bypass graft (CABG) surgery between May 2008 and October 2008 were included in this study. Internal thoracic artery, saphenous vein, and radial artery grafts were harvested. Specimens were taken to laboratory in +4 degrees C Krebs solution. Specimens were suspended in 10 ml organ bath containing Krebs solution. Results: Amiodarone caused relaxation in all grafts (ITA, RA, SV) between 10(-9)-10(-3,5) M concentration in a dose dependent manner (p<0.01). Maximum relaxation rates (mean) induced by amiodarone were 78.9%, 74.9% and 66.5% for ITA, RA and SV, respectively. Conclusion: Although we did not evaluate the endothelium-independent relaxation response in this study, higher rates of relaxation response were observed with ITA grafts comparing to other grafts, and these results were compatible with literature. According to the results of this study, amiodarone-class III antiarrhythmic agent- caused vasodilation in all three grafts in vitro. Vasodilator effect of amiodarone on grafts may help to increase patency rates.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2015.9871
dc.identifier.endpage18en_US
dc.identifier.issn1301-5680
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84921734347en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage14en_US
dc.identifier.trdizinid172742en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2015.9871
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/172742
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18367
dc.identifier.volume23en_US
dc.identifier.wosWOS:000348962500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal Of Thoracic And Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmiodaroneen_US
dc.subjectInternal Thoracic Arteryen_US
dc.subjectOrgan Bathen_US
dc.subjectRadial Arteryen_US
dc.subjectSaphenous Veinen_US
dc.subjectAtrial-Fibrillationen_US
dc.subjectCardiothoracic Surgeryen_US
dc.subjectHistorical Developmenten_US
dc.subjectPharmacologyen_US
dc.subjectRelaxationen_US
dc.subjectGuidelinesen_US
dc.titleIn vitro effects of amiodarone on coronary artery bypass graftsen_US
dc.typeArticleen_US

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