Subclinical Cushing's syndrome is a potential cause of metabolic dementia and rapidly progressive Alzheimer-type dementia

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dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.contributor.authorGuldiken, Sibet
dc.contributor.authorGuldiken, Baburhan
dc.date.accessioned2024-06-12T11:17:30Z
dc.date.available2024-06-12T11:17:30Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractExcess of glucocorticoid hormones are found to exert deleterious effects on the structure and function of central nervous system, especially the hippocampus. This is manifested as mental and mood changes in Cushing syndrome. Subclinical Cushing's syndrome (SCS) is much more prevalent than Cushing's syndrome, and presents with increased plasma cortisol levels, but tack of the cardinal manifestations of Cushing's syndrome. In dementia, the impairment of hypothalamic-pituitary-adrenal axis has been shown, and hypercortisolism has been accused for rapidly progressive cognitive decline in Alzheimer disease. We hypothesized that SCS may cause metabolic dementia, and should be searched in case of rapidly progressive dementia of Alzheimer type. (C) 2008 Published by Elsevier Ltd.en_US
dc.identifier.doi10.1016/j.mehy.2008.05.036
dc.identifier.endpage705en_US
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.issue5en_US
dc.identifier.pmid18801622en_US
dc.identifier.scopus2-s2.0-52949091502en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage703en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2008.05.036
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24736
dc.identifier.volume71en_US
dc.identifier.wosWOS:000260948700014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdrenal Incidentalomaen_US
dc.subjectCortisolen_US
dc.subjectBrainen_US
dc.subjectReceptoren_US
dc.subjectCorticosteroidsen_US
dc.subjectHippocampusen_US
dc.subjectNeuronsen_US
dc.titleSubclinical Cushing's syndrome is a potential cause of metabolic dementia and rapidly progressive Alzheimer-type dementiaen_US
dc.typeArticleen_US

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