Prognostic Effect of Albumin-Bilirubin Grade on Survival in Advance Gastric Cancer Patients with de-novo Liver Metastasis

Basit Öğe Kaydı
dc.contributor.authorKüçükarda, Ahmet
dc.contributor.authorGökyer, Ali
dc.contributor.authorGökmen, İvo
dc.contributor.authorKöstek, Osman
dc.contributor.authorHacıoglu, Muhammet Bekir
dc.contributor.authorUzunoğlu, Sernaz
dc.contributor.authorErdoğan, Bülent
dc.date.accessioned2024-06-12T10:05:18Z
dc.date.available2024-06-12T10:05:18Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: We aimed to explore the prognostic effect of albumin-bilirubin scores on survival prior to the treatment of patientswith gastric cancer with de-novo liver metastasis. Material and Methods: Retrospective screening was conducted on 203 patients who werefollowed up in our clinic. Two different models have been developed to compare the effect of albumin and bilirubin alone based on the albumin-bilirubin score. Albumin and bilirubin values in Model 1 and albumin-bilirubin grade in Model 2 were included in multivariate analysis. Results: Median age of the patients was 63, and 78.8% of the study population was male. There were 57 (28.1%) patients in thealbumin-bilirubin grade 1 group, 95 (46.8%) patients inthe albumin-bilirubin grade 2 group, whereas, 51 (25.1%) patients in the albumin-bilirubin grade 3 group. Median progression-free survival accordingto albumin-bilirubin grades 1-2-3 was8.9 (6.1-11.6) months, 4.2 (2.8-5.5)months, and 0.9 (0.7-1.2) months, respectively (p<0.01). In univariate analysis, poor prognostic effects of high albumin-bilirubin grade werereflected in bothprogression-free survival and overall survival. Multivariate analyzes revealed that in model 1; albumin <3.5 gr/dL and bilirubin >1.2 gr/dL values were prognostic for both progression-free survival and overall survival. In model 2, albumin-bilirubin grade was an independent prognostic factor for progression-free survival and overall survival. {[H 3.45 (1.98-6.02)] in progression-free survival and [H 4.41(2.45-7.93)] in overall survival for albumin-bilirubin grade 3}. Conclusion: High albumin-bilirubin score (grade) is much more sensitive ascompared to low albumin and high bilirubin values alone in showing poor prognosis on progression-free survival and overall survival in patients with gastric cancer with liver metastasis.en_US
dc.identifier.doi10.37047/jos.2020-77649
dc.identifier.endpage140en_US
dc.identifier.issn2651-4532
dc.identifier.issue3en_US
dc.identifier.startpage133en_US
dc.identifier.trdizinid423339en_US]
dc.identifier.urihttps://doi.org/10.37047/jos.2020-77649
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/423339
dc.identifier.urihttps://hdl.handle.net/20.500.14551/13348
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofJournal of oncological sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titlePrognostic Effect of Albumin-Bilirubin Grade on Survival in Advance Gastric Cancer Patients with de-novo Liver Metastasisen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu