Association of HER-2/neu overexpression with the number of involved axillary lymph nodes in hormone receptor positive breast cancer patients
Küçük Resim Yok
Tarih
2005
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Inst Exp Pathol Oncol Radiobiol
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: To evaluate the prognostic significance of HER-2/neu overexpression in hormone receptor and axillary lymph node positive breast cancer patients treated in a single institution. Methods: Paraffin-embedded primary breast cancers from 40 patients with invasive ductal carcinoma were studied immunohistochemically. HER-2/neu staining was classified as negative (0, 1+), weak/moderate positive (2+), or moderate/strong positive (3+) and was assessed for effectiveness as a predictor of outcome in univariate and Cox model multivariate analyses. Results: 20% of patients were positive for HER-2/neu. Significant associations were observed between HER-2/neu and increasing number of involved nodes (p = 0.014), p53 positivity (p = 0.039), the presence of vascular invasion (p = 0.029) and metastases (p = 0.01). Multivariate analysis demonstrated that HER-2/neu overexpression (p = 0.016) and age (p = 0.005) were independent predictors for disease-free survival (DFS) where the number of involved nodes (p = 0.032) was shown to be independent predictor for overall survival. In the HER-2/neu positively stained tumors, significant number of patients developed distant metastases than the patients with HER-2/neu negatively stained tumors (87.5% vs 34.4%, p = 0.01). Conclusion: For node positive patients, HER-2/neu overexpression was a significant predictor of DFS.
Açıklama
Anahtar Kelimeler
Axillary Lymph Node Involvement, Breast Cancer, HER-2/Neu, Prognosis, In-Situ Hybridization, Prognostic Value, P53 Expression, C-Erbb-2 Overexpression, Gene Amplification, Tissue Microarrays, Survival, Carcinomas, Oncogene, Protein
Kaynak
Experimental Oncology
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
27
Sayı
2
