Preformulation of Immediate Release Candesartan Cilexetil Tablets Using Full Factorial Experimental Design

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dc.authorwosidKarahan, Sevilay/E-8815-2013
dc.authorwosidÇapan, Yılmaz/AAM-5292-2021
dc.authorwosidGÜVEN, OLGUN/HHZ-1107-2022
dc.contributor.authorYuce, Meral
dc.contributor.authorGuven, Olgun
dc.contributor.authorKarahan, Sevilay
dc.contributor.authorSaracbasi, Osman
dc.contributor.authorCapan, Yilmaz
dc.date.accessioned2024-06-12T10:58:11Z
dc.date.available2024-06-12T10:58:11Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis work aimed compatibility and stability studies, five factor and two level (25) full factorial experimental design of immediate release candesartan cilexetil 32 mg tablets. Candesartan cilexetil is a drug substance, which has low solubility and chemical instability properties. Polyethylene glycol (PEG) 4000 showed stability protective property on candesartan cilexetil in tablets. Structural degradation of candesartan cilexetil was prevented by chemical reactions of terminal hydroxyl groups of PEG 4000 with carboxyl, N-H, N=N and anhydride groups of candesartan cilexetil. Stability protective mechanism was realized by converting crystalline candesartan cilexetil to amorphous form inside the amorphous region of PEG 4000. Stability evaluation showed that candesartan cilexetil could be protected ideally by PEG 4000 concentration of 2.5-10 % (w/w) in tablets. Dissolved drug from tablet could be predicted with high capability from statistical model, resulted from experimental design. Thus, stability and dissolution properties of candesartan cilexetil could be controlled in developed tablets.en_US
dc.identifier.endpage930en_US
dc.identifier.issn0326-2383
dc.identifier.issue5en_US
dc.identifier.startpage921en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19975
dc.identifier.volume35en_US
dc.identifier.wosWOS:000381938000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.relation.ispartofLatin American Journal Of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCompatibilityen_US
dc.subjectDissolutionen_US
dc.subjectStabilityen_US
dc.subjectDissolutionen_US
dc.titlePreformulation of Immediate Release Candesartan Cilexetil Tablets Using Full Factorial Experimental Designen_US
dc.typeArticleen_US

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