Partial sleep deprivation therapy combined with sertraline affects subjective sleep quality in major depressive disorder

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dc.authoridCaliyurt, Okan/0000-0002-0513-0619
dc.authorwosidCaliyurt, Okan/ABE-7339-2020
dc.contributor.authorCaliyurt, O
dc.contributor.authorGuducu, F
dc.date.accessioned2024-06-12T11:14:13Z
dc.date.available2024-06-12T11:14:13Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and purpose: Earlier studies have shown an association between mood disorders and sleep regulation. Total or partial sleep deprivation was demonstrated to have rapid antidepressive effects in depression. Depressive symptoms recur after one night of recovery sleep, but relapse is less when patients are receiving medication. In this study, we examined the subjective sleep quality changes with the antidepressive therapy using partial sleep deprivation plus sertraline and sertraline monotherapy in patients with major depressive disorder. Patients and methods: Thirteen patients received six partial sleep deprivation therapies in addition to sertraline; the sleep schedule on deprivation nights started at 11:00 p.m. and ended at 3:00 a.m. Eleven patients were treated with sertraline monotherapy as a control group. Six nights of partial sleep deprivation were completed in the first two weeks. Subjective sleep quality was evaluated with the Pittsburgh Sleep Quality Index (PSQ1); depression and the accompanying anxiety were also assessed at baseline and at the end of the fourth week. Results: The late partial sleep deprivation (LPSD) group showed less increase in estimated sleep duration and less significant improvement in subjective sleep quality than the control group. Although decreased sleep latency and increased sleep efficiency are associated with the sleep deprivation, contrary results were found in our study. Conclusions: In conclusion, changes in subjective sleep quality could occur relative to the combined partial sleep deprivation therapy and to pharmacotherapy and must be differentiated from the rapid effects of sleep deprivation therapy and objective polysomnographic measures. (c) 2005 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.sleep.2005.04.007
dc.identifier.endpage559en_US
dc.identifier.issn1389-9457
dc.identifier.issn1878-5506
dc.identifier.issue6en_US
dc.identifier.pmid15994121en_US
dc.identifier.scopus2-s2.0-27944441665en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage555en_US
dc.identifier.urihttps://doi.org/10.1016/j.sleep.2005.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23853
dc.identifier.volume6en_US
dc.identifier.wosWOS:000233577000012en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSleep Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSleep Deprivationen_US
dc.subjectSleep Qualityen_US
dc.subjectSertralineen_US
dc.subjectMajor Depressionen_US
dc.subjectInsomniaen_US
dc.subjectManiaen_US
dc.titlePartial sleep deprivation therapy combined with sertraline affects subjective sleep quality in major depressive disorderen_US
dc.typeArticleen_US

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