Morphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 years

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dc.authoridBaysal, Mehmet/0000-0001-7681-4623
dc.authoridDemirci, Ufuk/0000-0001-6923-1470
dc.authorwosidBaysal, Mehmet/E-9111-2018
dc.contributor.authorDemirci, Ufuk
dc.contributor.authorUmit, Elif Gulsum
dc.contributor.authorBaysal, Mehmet
dc.contributor.authorDemir, Ahmet Muzaffer
dc.date.accessioned2024-06-12T10:59:56Z
dc.date.available2024-06-12T10:59:56Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: In immune thrombocytopenia (ITP), which is a common acquired bleeding disorder, cytotoxic T-cell-mediated cellular immune response against both circulating platelets and bone marrow megakaryocytes are the most important mechanisms in the pathogenesis. METHODS: In our study, we evaluated the features of 33 patients with ITP, over 80 years of age. RESULTS: The median age of the patients was 90, 15 patients were female (45.4%). The mean platelet count of the patients was 39x109/L and the mean mean platelet volume was 10,33fL. Twelve patients had a target thrombocyte count greater than 30x109/L, while 20 patients had a target platelet count of 75x109/L or greater with an absolute indication of antiaggregation. In the environmental spread, 18 dysplasia findings were observed. CONCLUSION: Morphologic observations suggesting dysplasia including micromegakaryocytes and a non-dysplastic but dysmegakaryopoietic finding, multiple segmented nuclei may be related to the degree of thrombocytopenia and response to treatment. Likewise, nondysplastic features including immature forms, emperipolesis, bare nucleus, hypolobulation, and hypersegmented nucleus were related to the degree of thrombocytopenia.en_US
dc.identifier.doi10.14744/nci.2022.57124
dc.identifier.endpage483en_US
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue4en_US
dc.identifier.pmid37719257en_US
dc.identifier.scopus2-s2.0-85168960067en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage477en_US
dc.identifier.urihttps://doi.org/10.14744/nci.2022.57124
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20635
dc.identifier.volume10en_US
dc.identifier.wosWOS:001089160600010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofNorthern Clinics Of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDysmegakaryopoiesisen_US
dc.subjectDysplasiaen_US
dc.subjectImmune Thrombocytopeniaen_US
dc.subjectMegakaryocyte.en_US
dc.subjectEpidemiologyen_US
dc.subjectPurpuraen_US
dc.titleMorphologic evaluation of megakaryocytes in immune thrombocytopenia patients older than 80 yearsen_US
dc.typeArticleen_US

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