In Vitro Effects of Dopamine on Internal Thoracic Artery Graft Used in Coronary Artery Bypass Surger

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dc.authoridHalici, Umit/0000-0002-1289-8829
dc.authoridHalici, Umit/0000-0002-1289-8829
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidHalici, Umit/AAL-7079-2020
dc.authorwosidHalici, Umit/C-4015-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorHalici, Umit
dc.contributor.authorEge, Turan
dc.contributor.authorKaradag, Cetin Hakan
dc.contributor.authorDuran, Enver
dc.date.accessioned2024-06-12T11:03:55Z
dc.date.available2024-06-12T11:03:55Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to investigate in vitro effects of dopamine on internal thoracic artery (ITA) graft. Material and Methods: Between December 2003- June 2005, 32 patients (2 women and 30 men, mean age; 59.26+/-8.34, range 37-75 years old) who were subjected to coronary artery bypass grafting (CABG) operation in our clinic were enrolled in this study. ITA remnants were suspended in an isolated organ bath. Constrictor or relaxant responses to dopamine were recorded isometrically. Results: Dopamine in the concentration range of 10(-9) M-10(-7) M produced a mild relaxant effect on phenylephrine-precontracted ITA, and at higher concentrations than 10(-7) M it produced a constrictor response. Ther relaxant effect of dopamine was partially antagonized by L-NAME (nitric oxide synthase inhibitor, 10(-6) M), propranolol (10(-6) M), and cis-alpha-flupenthixol (dopaminergic receptor antagonist, 10(-6) M), but not by metoclopramide (D-2-dopaminergic receptor antagonist). The constrictor effect of dopamine was partially antagonized by phentolamine, prazosin and, yohimbine. Conclusion: It was concluded that, while dopamine produces a vasodilator response at the lower concentrations, it causes a constrictor effect on ITA at the higher concentrations. Both a beta-adrenergic and a nitric oxide mediated mechanism (via D-1-dopaminergic receptor) may play a role in the relaxant effect of dopamine on ITA at the lower concentrations. Constrictor response to dopamine at the higher concentrations on ITA may be produced by the activation of alpha(1)- and alpha(2)-adrenergic receptors.en_US
dc.identifier.doi10.5174/tutfd.2009.01869.1
dc.identifier.endpage350en_US
dc.identifier.issn1301-3149
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-79952145181en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage344en_US
dc.identifier.urihttps://doi.org/10.5174/tutfd.2009.01869.1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21841
dc.identifier.volume27en_US
dc.identifier.wosWOS:000287686200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInternal Thoracic Arteryen_US
dc.subjectCoronary Artery Bypass Surgeryen_US
dc.subjectDopamineen_US
dc.subjectMammary Arteryen_US
dc.subjectGastroepiploic Arteriesen_US
dc.subjectReceptor Subtypesen_US
dc.subjectLocalizationen_US
dc.subjectReactivityen_US
dc.subjectContractilityen_US
dc.subjectIncreasesen_US
dc.subjectAgentsen_US
dc.subjectSpasmen_US
dc.subjectVeinsen_US
dc.titleIn Vitro Effects of Dopamine on Internal Thoracic Artery Graft Used in Coronary Artery Bypass Surgeren_US
dc.typeArticleen_US

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