Evaluation of tumor angiogenesis with contrast-enhanced dynamic magnetic resonance mammography
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The goal of this research was to correlate dynamic magnetic resonance (MR) mammographic contrast enhancement and microvessel densities in breast masses. Forty-six female patients with breast masses detected by mammography and/or ultrasonography were included in the study. MR contrast enhancements of the lesions were investigated dynamically using axial three-dimensional fast low-angle shot sequences. After excisional biopsy or mastectomy, immunohistochemical staining with factor VIII-RA was performed, followed by microvessel density measurements. Contrast enhancement patterns in dynamic MR mammography were compared with microvessel density measurements using Student's t-test, Pearson's moment correlation coefficients, and one-way analysis of variance (ANOVA). Malignant lesions exhibited three different enhancement patterns: 1) a peak enhancement within 120 seconds (early phase), followed by a decrease in the delayed phase (25 cases); 2) an increase in the early phase, followed by a plateau in the delayed phase (9 cases); and 3) an increase throughout the examination without any peak (5 cases). In benign lesions, signal intensity did not exhibited a peak in five cases, whereas in two cases enhancement was increased in the early phase and made a plateau in the delayed phase. A significant correlation was found between microvessel density and the percentage of maximal signal increase following paramagnetic contrast administration (r= 0.322, p < 0.05). Dynamic enhancement patterns and rates of maximal signal increase predict microvessel density in breast malignancies and may possibly be used as prognostic indicators.
Açıklama
Anahtar Kelimeler
Angiogenesis; Breast Cancer; Dynamic Mr Mammography; Microvessel Density, Adult; Aged; Angiogenesis; Article; Breast Cancer; Cancer Research; Cell Viability; Clinical Article; Contrast Enhancement; Female; Histopathology; Human; Lymph Node Biopsy; Mammography; Mastectomy; Microvasculature; Nuclear Magnetic Resonance; Prognosis; Tumor Growth; Tumor Volume; Adult; Aged; Aged, 80 And Over; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Carcinoma, Medullary; Contrast Media; Female; Fibroadenoma; Humans; Immunohistochemistry; Magnetic Resonance Imaging; Mammography; Middle Aged; Neovascularization, Pathologic; Predictive Value Of Tests
Kaynak
Breast Journal
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
9
Sayı
5
