Investigation of the relationship between GSTM1 gene variations and serum trace elements, plasma malondialdehyde levels in patients with colorectal cancer

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dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authoridAlkanli, Nevra/0000-0002-3745-8838
dc.authoridKOCAK, ZAFER/0000-0003-1918-7795
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.contributor.authorAy, Arzu
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorSipahi, Tammam
dc.contributor.authorCicin, Irfan
dc.contributor.authorKocak, Zafer
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:58:07Z
dc.date.available2024-06-12T10:58:07Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground The aim of this study is to investigate of the relationship between GSTM1 gene variations and serum trace elements, plasma malondialdehyde levels in patient with colorectal cancer. Mateials and Methods. Genotype distributions of GSTM1 gene variations were determined using real-time polymerase chain reaction method. Serum trace element levels were determined using atomic absorption spectrophotometer method and plasma MDA levels were measurement by spectrophotometric method. Results Serum Cu levels, plasma MDA levels and Cu/Zn ratio were determined significantly higher in the group of CRC patient carrying the GA heterozygous genotype of the GSTM1 (rs 112,778,559) gene variation compared to healthy controls (p < 0.05). Serum Cu, Zn levels, plasma MDA levels and Cu/Zn ratio were determined significantly higher in patients carrying GG homozygous genotype of the GSTM1 (rs 112778559) gene variation compared to healthy controls carrying same genotype (p < 0.05). Serum Cu, Zn levels, plasma MDA levels and Cu/Zn ratio were determined significantly higher in the group of CRC patient carrying the GG homozygous genotype of the GSTM1 (rs 12068997) gene variation compared to healthy controls (p < 0.05). On the other hand, serum Se levels were detected significantly lower in CRC patients carrying GA heterozygous and GG homozygous genotypes for GSTM1 (rs 112,778,559) and (rs 12,068,997) gene variations compared to healthy controls (p < 0.05). Conclusion In our study, the evaluation of serum Cu, Zn and Se trace element levels and plasma MDA levels according to GSTM1 gene variations genotype distributions were enabled to obtain important biomarkers in terms of CRC development and progression.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit (TUBAP) [2013/14]en_US
dc.description.sponsorshipThis study was supported by the Trakya University Scientific Research Projects Unit (TUBAP) with the project number 2013/14.en_US
dc.identifier.doi10.1007/s11033-021-06694-2
dc.identifier.endpage6921en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue10en_US
dc.identifier.pmid34498162en_US
dc.identifier.scopus2-s2.0-85114438976en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6911en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-021-06694-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19951
dc.identifier.volume48en_US
dc.identifier.wosWOS:000693893900003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal Canceren_US
dc.subjectGSTM1 Gene Variationsen_US
dc.subjectReal-Time PCRen_US
dc.subjectSerum Trace Elements Levelsen_US
dc.subjectPlasma Malondialdehyde Levelsen_US
dc.subjectOxidative Stressen_US
dc.subjectPolymorphismsen_US
dc.subjectRisken_US
dc.subjectAssociationen_US
dc.subjectMetalsen_US
dc.subjectCyp1a1en_US
dc.subjectGstt1en_US
dc.subjectZnen_US
dc.subjectCuen_US
dc.titleInvestigation of the relationship between GSTM1 gene variations and serum trace elements, plasma malondialdehyde levels in patients with colorectal canceren_US
dc.typeArticleen_US

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