Portobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacterium

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dc.authoridLeao, Tiago/0000-0003-1034-9153
dc.authoridGerwick, William/0000-0003-1403-4458
dc.authorwosidalmaliti, jehad/R-7507-2016
dc.contributor.authorDemirkiran, Ozlem
dc.contributor.authorAlmaliti, Jehad
dc.contributor.authorLeao, Tiago
dc.contributor.authorNavarro, Gabriel
dc.contributor.authorByrum, Tara
dc.contributor.authorValeriote, Frederick A.
dc.contributor.authorGerwick, Lena
dc.date.accessioned2024-06-12T11:18:40Z
dc.date.available2024-06-12T11:18:40Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThree new compounds, portobelamides A and B (1 and 2), 3-amino-2-methyl-7-octynoic acid (AMOYA) and hydroxyisovaleric acid (Hiva) containing cyclic depsipeptides, and one long chain lipopeptide caciqueamide (3), were isolated from a field-collection of a Caldora sp. marine cyanobacterium obtained from Panama as part of the Panama International Cooperative Biodiversity Group Program. Their planar structures were elucidated through analysis of 2D NMR and MS data, especially high resolution (HR) MS2/MS3 fragmentation methods. The absolute configurations of compounds 1 and 2 were deduced by traditional hydrolysis, derivative formation, and chromatographic analyses compared with standards. Portobelamide A (1) showed good cytotoxicity against H-460 human lung cancer cells (33% survival at 0.9 mu M).en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK); UCSD Compound Library Initiative; NIH [GM107550, U01 TW006634, CA100851]; Gordon and Betty Moore Foundation [GBMF7622]en_US
dc.description.sponsorshipO.D. is grateful to The Scientific and Technological Research Council of Turkey (TUBITAK) for a fellowship that enabled her to conduct research at the Scripps Institution of Oceanography, UCSD. We thank G. Humphrey, J. Sanders, and R. Knight for the genome sequencing efforts. We thank UCSD Chancellor P. Khosla for support of a UCSD Compound Library Initiative. Work at UCSD was conducted with support from NIH grants GM107550, U01 TW006634, and CA100851 and the Gordon and Betty Moore Foundation grant GBMF7622.en_US
dc.identifier.doi10.1021/acs.jnatprod.0c01383
dc.identifier.endpage2093en_US
dc.identifier.issn0163-3864
dc.identifier.issn1520-6025
dc.identifier.issue8en_US
dc.identifier.pmid34269583en_US
dc.identifier.scopus2-s2.0-85111214180en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2081en_US
dc.identifier.urihttps://doi.org/10.1021/acs.jnatprod.0c01383
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24909
dc.identifier.volume84en_US
dc.identifier.wosWOS:000692038100003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofJournal Of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclic Depsipeptidesen_US
dc.subjectAlignmenten_US
dc.subjectGenesen_US
dc.titlePortobelamides A and B and Caciqueamide, Cytotoxic Peptidic Natural Products from a Caldora sp. Marine Cyanobacteriumen_US
dc.typeArticleen_US

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