Preventive effects of hyperbaric oxygen treatment on glycerol-induced myoglobinuric acute renal failure in rats

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dc.authoridColak, Alkin/0000-0001-9103-4844
dc.authoridbasaran, umit nusret/0000-0002-9977-6655
dc.authoridUzun, Hafize/0000-0002-1347-8498
dc.authorwosidColak, Alkin/R-8739-2017
dc.authorwosidUzun, Hafize/D-4811-2019
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorAksu, Burhan
dc.contributor.authorKanter, Mehmet
dc.contributor.authorUzun, Hafize
dc.contributor.authorErboga, Mustafa
dc.contributor.authorColak, Alkin
dc.contributor.authorBasaran, Umit Nusret
dc.date.accessioned2024-06-12T10:52:27Z
dc.date.available2024-06-12T10:52:27Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMyoglobinuric acute renal failure (ARF) is a uremic syndrome caused by traumatic or non-traumatic skeletal muscle breakdown and intracellular elements that are released into the bloodstream. We hypothesized that hyperbaric oxygen (HBO) therapy could be beneficial in the treatment of myoglobinuric ARF caused by rhabdomyolysis. A total of 32 rats were used in the study. The rats were divided into four groups: control, control+hyperbaric oxygen (control+HBO), ARF, and ARF+hyperbaric oxygen (ARF+HBO). Glycerol (8 ml/kg) was injected into the hind legs of each of the rats in ARF and ARF+HBO groups. 2.5 atmospheric absolute HBO was applied to the rats in the control+HBO and ARF+HBO groups for 90 min on two consecutive days. Plasma urea, creatinine, sodium, potassium, calcium, aspartate aminotransferase, alanine aminotransferase, lactic dehydrogenase, creatinine kinase and urine creatinine and sodium were examined. Creatinine clearance and fractional sodium excretion could then be calculated. Superoxide dismutase, catalase, glutathione and malondialdehyde (MDA) levels were assessed in renal tissue. Tissue samples were evaluated by Hematoxylin-eosin, PCNA and TUNEL staining histopathologically. MDA levels were found to be significantly decreased whereas SOD and CAT were twofold higher in the ARF+HBO group compared to the ARF group. Renal function tests were ameliorated by HBO therapy. Semiquantitative evaluation of histopathological findings indicated that necrosis and cast formation was decreased by HBO therapy and TUNEL staining showed that apoptosis was inhibited. PCNA staining showed that HBO therapy did not increase regeneration. Ultimately, we conclude that, in accordance with our hypothesis, HBO could be beneficial in the treatment of myoglobinuric ARF.en_US
dc.description.sponsorshipTrakya University Research Center, Edirne, Turkey [TUBAB 2011-41]en_US
dc.description.sponsorshipThis study was supported as Project TUBAB 2011-41 by Trakya University Research Center, Edirne, Turkey.en_US
dc.identifier.doi10.1007/s10735-012-9391-5
dc.identifier.endpage170en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue2en_US
dc.identifier.pmid22311626en_US
dc.identifier.scopus2-s2.0-84861094034en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage161en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-012-9391-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18693
dc.identifier.volume43en_US
dc.identifier.wosWOS:000303357100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectFree Radicalsen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectMyoglobinuric Acute Renal Failureen_US
dc.subjectRhabdomyolysisen_US
dc.subjectInduced Nephrotoxicityen_US
dc.subjectCompartment Syndromeen_US
dc.subjectFree-Radicalsen_US
dc.subjectCrush Injuryen_US
dc.subjectTherapyen_US
dc.subjectRhabdomyolysisen_US
dc.subjectPathogenesisen_US
dc.subjectMechanismsen_US
dc.subjectApoptosisen_US
dc.subjectIronen_US
dc.titlePreventive effects of hyperbaric oxygen treatment on glycerol-induced myoglobinuric acute renal failure in ratsen_US
dc.typeArticleen_US

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